Slc18a1 - solute carrier family 18 (vesicular monoamine), member 1 Gene

Also Known as Vat1; Vmat1; 4832416I10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110877

Summary

Predicted to enable enzyme binding activity and serotonin:sodium symporter activity. Predicted to be involved in aminergic neurotransmitter loading into synaptic vesicle; regulation of ion transport; and serotonin uptake. Predicted to act upstream of or within neurotransmitter transport. Located in synapse. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; immune system; and nervous system. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human SLC18A1 (solute carrier family 18 member A1). [provided by Alliance of Genome Resources, Apr 2022]

Slc18a1 Products (1)

mRNA Protein Name
NM_153054.2 NP_694694.1 chromaffin granule amine transporter

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables monoamine:proton antiporter activity IDA
IDA: Inferred from direct assay
21712771 MGI
Biological Process GO Annotation Evidence References Source
involved in serotonin uptake IDA
IDA: Inferred from direct assay
21712771 MGI
Cellular Component GO Annotation Evidence References Source
is active in synapse IDA
IDA: Inferred from direct assay
23201251 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chromaffin granule amine transporter

  • solute carrier family 18 member 1

  • vesicular amine transporter 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13043 SLC18A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-D3197 CDg16 / Unkown
HY-RS13046 SLC18B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22034 Slc18b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc18a1 NCBI NCBI:6570