SLC18A1 - solute carrier family 18 member A1 Gene

Also Known as CGAT; VAT1; VMAT1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6570

About SLC18A1

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:20,144,855-20,183,136 (from NCBI)

This gene has 10 transcripts (splice variants), 196 orthologues and 3 paralogues. Biased expression in adrenal (RPKM 13.1), colon (RPKM 1.0) and 1 other tissue.

Summary

The vesicular Monoamine Transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]

SLC18A1 Products (4)

mRNA	Protein	Name
NM_001135691.3	NP_001129163.1	chromaffin granule amine transporter isoform a
NM_001142324.2	NP_001135796.1	chromaffin granule amine transporter isoform b
NM_001142325.2	NP_001135797.1	chromaffin granule amine transporter isoform c
NM_003053.4	NP_003044.1	chromaffin granule amine transporter isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables monoamine:proton antiporter activity	IDA IDA: Inferred from direct assay	8643547	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in dopamine uptake	IDA IDA: Inferred from direct assay	23337945	GOA
involved in norepinephrine uptake	IDA IDA: Inferred from direct assay	23337945	GOA
involved in serotonin uptake	IDA IDA: Inferred from direct assay	8643547	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	16326835	GOA
located in secretory granule membrane	IDA IDA: Inferred from direct assay	16326835	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC18A1 Protein Structure

MFS_1

0
100
200
300
400
500
525 a.a.

Protein Preferred Names	Protein Names
chromaffin granule amine transporter	solute carrier family 18 (vesicular monoamine transporter), member 1

Related Diseases

Diseases	Alias
Barbiturate Abuse
Adrenal Neuroblastoma	Neuroblastoma Of Adrenal Gland Adrenal Gland Neuroblastoma Neuroblastoma Nos
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13043	SLC18A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-D3197	CDg16		/	Unkown
HY-RS13046	SLC18B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22034	Slc18b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC18A1	MGD	MGI:106684
Bos taurus	SLC18A1	VGNC	VGNC:34705
Canis familiaris	SLC18A1	VGNC	VGNC:46255
Felis catus	SLC18A1	VGNC	VGNC:65226
Rattus norvegicus	SLC18A1	RGD	RGD:3693
Macaca mulatta	SLC18A1	VGNC	VGNC:77406
Others	SLC18A1	NCBI