PRSS23 - serine protease 23 Gene

Also Known as SIG13; SPUVE; ZSIG13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11098

About PRSS23

Cytogenetic location: 11q14.2 Genomic coordinates (GRCh38): 11:86,791,071-86,952,910 (from NCBI)

This gene has 9 transcripts (splice variants), 176 orthologues and 1 paralogue. Ubiquitous expression in gall bladder (RPKM 19.0), urinary bladder (RPKM 17.9) and 24 other tissues.

Summary

This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

PRSS23 Products (3)

mRNA	Protein	Name
NM_001293179.2	NP_001280108.1	serine protease 23 precursor
NM_001293180.2	NP_001280109.1	serine protease 23 precursor
NM_007173.6	NP_009104.3	serine protease 23 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRSS23 Protein Structure

Trypsin

0
100
200
300
383 a.a.

Protein Preferred Names	Protein Names
serine protease 23	protease, serine 23

PRSS23 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRSS23	O95084	SEC11C	Homo sapiens	Q9BY50	Validated Y2H	32296183
Intra	PRSS23	O95084	SEC11C	Homo sapiens	Q9BY50	Y2H Prey Pooling	32296183
Intra	PRSS23	O95084	SEC11C	Homo sapiens	Q9BY50	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Exudative Vitreoretinopathy 1	Retinopathy Of Prematurity Retrolental Fibroplasia EVR1 Criswick-Schepens Syndrome Rop Exudative Vitreoretinopathy, Familial, Autosomal Dominant Fevr, Autosomal Dominant Premature Retinopathy Vitreoretinopathy, Exudative 1 Autosomal Dominant Familial Exudative Vitreoretinopathy Fevr Vitreoretinopathy, Exudative, Type 1 Retinopathy Of Prematurity Nos Rlf- [Retrolental Fibroplasia] Rop - [Retinopathy Of Prematurity] Terry Syndrome
Coats Disease	Exudative Retinopathy Retinal Telangiectasis Coats' Disease Leber Miliary Aneurysm Coats' Syndrome Congenital Retinal Telangiectasia
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Marginal Corneal Ulcer
Vascular Skin Disease	Skin Diseases, Vascular Skin Vascular Disease
Keipert Syndrome	Nasodigitoacoustic Syndrome KPTS Nasodigitoacoustic Syndrome, Formerly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11251	PRSS23 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21179	Prss23 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27696	Prss23 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRSS23	VGNC	VGNC:64397
Macaca mulatta	PRSS23	VGNC	VGNC:76253
Bos taurus	PRSS23	VGNC	VGNC:33416
Mus musculus	PRSS23	MGD	MGI:1923703
Rattus norvegicus	PRSS23	RGD	RGD:1359545
Canis familiaris	PRSS23	VGNC	VGNC:45065