INSL6 - insulin like 6 Gene

Also Known as RIF1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11172

About INSL6

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:4,991,976-5,185,639 (from NCBI)

This gene has 3 transcripts (splice variants), 96 orthologues and 3 paralogues. Restricted expression toward testis (RPKM 6.0).

Summary

The protein encoded by this gene contains a classical signature of the Insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development and fertilization. [provided by RefSeq, Jul 2008]

INSL6 Products (1)

mRNA Protein Name
NM_007179.3 NP_009110.2 insulin-like peptide INSL6 precursor

INSL6 Protein Structure

Insulin

Insulin: Insulin/IGF/Relaxin family (31 - 192)

  • 0
  • 100
  • 200
  • 213 a.a.
Protein Preferred Names Protein Names

insulin-like peptide INSL6

  • insulin-like peptide 5

Recombinant INSL6 Proteins

Cat. No. Product Name Accession Purity
HY-P76455 INSL6 Protein, Human (HEK293, His) Q9Y581/NP_009110.2 (R21-F198) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Myeloproliferative Neoplasm

  • Myeloproliferative Disorder

  • Chronic Myeloproliferative Disease

  • Myeloproliferative Neoplasms

  • Chronic Myeloproliferative Disorder

  • Cmpd

  • Cmpd, U

  • Chronic Myeloproliferative Disorders

  • Mpd

  • Mpn

  • Myeloproliferative Disorders

  • Myeloproliferative Disease

  • Campomelic Dysplasia
Polycythemia

  • Erythrocythemia

  • Polycythemia Vera

  • Polycythaemia Due To High Altitude
Lymphoblastic Leukemia, Acute, With Lymphomatous Features

  • LALL

  • Lymphomatous All

  • Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia With Lymphomatous Features
Thrombocythemia 3

  • THCYT3

  • Thrombocytosis 3
Budd-Chiari Syndrome

  • Hepatic Vein Thrombosis

  • Chiari Syndrome

  • BDCHS

  • Membranous Obstruction Of The Inferior Vena Cava

  • Budd-Chiari Syndrome, Somatic

  • Movc

  • Budd-Chiari Syndrome, Susceptibility To, Somatic

  • Budd-Chiari Syndrome, Susceptibility To

  • Membranous Obstruction Of Inferior Vena Cava

  • Hepatic Vein Block

  • Obstruction Of Hepatic Veins

  • Hepatic Vein Obstruction

  • Hepatic Venous Block
Polycythemia Vera

  • PV

  • Polycythemia Rubra Vera

  • Prv

  • Osler-Vaquez Disease

  • Chronic Erythremia

  • Polycythaemia Rubra Vera

  • Primary Polycythemia

  • Vaquez Disease

  • Polycythemia Vera, Somatic

  • Osler-Vaquez Syndrome

  • Proliferative Polycythaemia

  • Polycythemia Ruba Vera

  • Acquired Primary Erythrocytosis

  • Heilmeyer-Schoner Disease

  • Vaquez Osler Disease

  • Primary Polycythaemia
Erythrocytosis, Familial, 1

  • ECYT1

  • Pfcp

  • Primary Familial And Congenital Polycythemia

  • Familial Erythrocytosis 1

  • Familial Erythrocytosis

  • Polycythemia, Primary Familial And Congenital

  • Autosomal Dominant Benign Erythrocytosis

  • Familial Erythrocytosis Type 1

  • Congenital Erythrocytosis Due To Erythropoietin Receptor Mutation

  • Congenital Polycythemia Due To Erythropoietin Receptor Mutation

  • Primary Congenital Erythrocytosis

  • Primary Familial Polycythemia

  • Erythrocytosis, Autosomal Dominant Benign

  • Erythrocytosis, Somatic

  • Autosomal Dominant Familial Erythrocytosis-1

  • Erythrocytosis Autosomal Dominant Benign

  • Familial Primary Polycythemia

  • Familial Erythrocytosis, 1

  • Erythrocytosis, Familial, Type 1
Myelofibrosis

  • Primary Myelofibrosis

  • Agnogenic Myeloid Metaplasia

  • Idiopathic Myelofibrosis

  • Myeloid Metaplasia

  • Myelofibrosis With Myeloid Metaplasia

  • Osteomyelofibrosis

  • Megakaryocytic Myelosclerosis

  • Myelosclerosis

  • Chronic Idiopathic Myelofibrosis

  • Myelofibrosis, Idiopathic

  • Myelofibrosis With Myeloid Metaplasia, Somatic

  • Myelofibrosis, Somatic

  • Aleukemic Myelosis

  • Bone Marrow Fibrosis

  • MYELOF

  • MMM

  • Agnogenic Myeloid Metaplasia With Myelofibrosis

  • Ammm

  • Myelosclerosis With Myeloid Metaplasia

  • Myelofibrosis Nos
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Splenomegaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06843 INSL6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20965 Insl6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27482 Insl6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus INSL6 VGNC VGNC:30219
Felis catus INSL6 VGNC VGNC:102941
Mus musculus INSL6 MGD MGI:1351595
Rattus norvegicus INSL6 RGD RGD:62061
Canis familiaris INSL6 VGNC VGNC:42041
Others INSL6 NCBI