CHP1 - calcineurin like EF-hand protein 1 Gene

Homo sapiens

Also known as CHP; p22; p24; SPAX9; Sid470p; SLC9A1BP

Gene ID: 11261 | Gene type: protein coding

About CHP1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,231,268-41,281,887 (from NCBI)

This gene has 9 transcripts (splice variants), 230 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 59.2), liver (RPKM 56.3) and 25 other tissues.

Summary

This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with Calcineurin B and Calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]

CHP1 Products(1)

mRNA	Protein	Name
NM_007236.5	NP_009167.1	calcineurin B homologous protein 1

CHP1 Protein Structure

EF-hand_7

0
100
195 a.a.

Protein Preferred Names

Protein Names

calcineurin B homologous protein 1

EF-hand calcium-binding domain-containing protein p22

Related Diseases

Diseases

Alias

Spastic Ataxia 9, Autosomal Recessive

SPAX9

Lichtenstein-Knorr Syndrome

Scar19	LIKNS
Autosomal Recessive Spinocerebellar Ataxia 19	Spinocerebellar Ataxia, Autosomal Recessive 19
Progressive Autosomal Recessive Ataxia-Deafness Syndrome	Progressive Autosomal Recessive Ataxia-Sensorineural Hearing Loss Syndrome
Spinocerebellar Ataxia, Autosomal Recessive, 19

Cataract 3, Multiple Types

Cataract 3 Multiple Types	CTRCT3
Cca2	Cataract, Congenital, Cerulean Type, 2
Cataract 3, Multiple Types, With Or Without Microcornea	Cataract 3 Multiple Types With Or Without Microcornea
Congenital Cerulean Type Cataract 2	Congenital Cataract Blue Dot Type 2
Congenital Cataract Cerulean Type 2	Cspc
Sutural Cataract With Punctate And Cerulean Opacities

Spastic Paraparesis

Spastic Ataxia

Spax	Ataxia, Spastic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02652	CHP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CHP1	MGD	MGI:1927185
Canis familiaris	CHP1	VGNC	VGNC:39227
Bos taurus	CHP1	VGNC	VGNC:27310
Rattus norvegicus	CHP1	RGD	RGD:620447
Felis catus	CHP1	VGNC	VGNC:81003