CHP1 - calcineurin like EF-hand protein 1 Gene

Also Known as CHP; p22; p24; SPAX9; Sid470p; SLC9A1BP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11261

About CHP1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,231,268-41,281,887 (from NCBI)

This gene has 9 transcripts (splice variants), 230 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 59.2), liver (RPKM 56.3) and 25 other tissues.

Summary

This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with Calcineurin B and Calmodulin and it is also known to be an endogenous inhibitor of Calcineurin activity. [provided by RefSeq, Jul 2008]

CHP1 Products (1)

mRNA	Protein	Name
NM_007236.5	NP_009167.1	calcineurin B homologous protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	15035633	GOA
enables calcium-dependent protein binding	IDA IDA: Inferred from direct assay	15035633	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8901634	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	10593895	GOA
involved in negative regulation of calcineurin-NFAT signaling cascade	IDA IDA: Inferred from direct assay	10593895	GOA
involved in negative regulation of phosphatase activity	IDA IDA: Inferred from direct assay	10593895	GOA
involved in negative regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	10593895	GOA
involved in positive regulation of phospholipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	30846317	GOA
involved in positive regulation of sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	8901634	GOA
involved in regulation of intracellular pH	IDA IDA: Inferred from direct assay	8901634	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11350981	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	29379881	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHP1 Protein Structure

EF-hand_7

0
100
195 a.a.

Protein Preferred Names	Protein Names
calcineurin B homologous protein 1	EF-hand calcium-binding domain-containing protein p22

CHP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CHP1	Q99653	SLC9A1	Homo sapiens	P19634	Fluorescence	31912575
Intra	CHP1	Q99653	SLC9A1	Homo sapiens	P19634	ITC	31912575
Intra	CHP1	Q99653	SLC9A1	Homo sapiens	P19634	MST	31912575

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spastic Ataxia 9, Autosomal Recessive	SPAX9
Lichtenstein-Knorr Syndrome	Scar19 LIKNS Autosomal Recessive Spinocerebellar Ataxia 19 Spinocerebellar Ataxia, Autosomal Recessive 19 Progressive Autosomal Recessive Ataxia-Deafness Syndrome Progressive Autosomal Recessive Ataxia-Sensorineural Hearing Loss Syndrome Spinocerebellar Ataxia, Autosomal Recessive, 19
Cataract 3, Multiple Types	Cataract 3 Multiple Types CTRCT3 Cca2 Cataract, Congenital, Cerulean Type, 2 Cataract 3, Multiple Types, With Or Without Microcornea Cataract 3 Multiple Types With Or Without Microcornea Congenital Cerulean Type Cataract 2 Congenital Cataract Blue Dot Type 2 Congenital Cataract Cerulean Type 2 Cspc Sutural Cataract With Punctate And Cerulean Opacities
Spastic Paraparesis
Spastic Ataxia	Spax Ataxia, Spastic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02652	CHP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21312	Chp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27831	Chp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CHP1	MGD	MGI:1927185
Canis familiaris	CHP1	VGNC	VGNC:39227
Bos taurus	CHP1	VGNC	VGNC:27310
Rattus norvegicus	CHP1	RGD	RGD:620447
Felis catus	CHP1	VGNC	VGNC:81003
Others	CHP1	NCBI