NADK2 - NAD kinase 2, mitochondrial Gene

Homo sapiens

Also known as DECRD; MNADK; NADKD1; C5orf33

Gene ID: 133686 | Gene type: protein coding

About NADK2

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:36,192,589-36,242,279 (from NCBI)

This gene has 11 transcripts (splice variants), 211 orthologues and is associated with 3 phenotypes. Broad expression in liver (RPKM 62.0), brain (RPKM 14.1) and 22 other tissues.

Summary

This gene encodes a mitochondrial kinase that catalyzes the phosphorylation of NAD to yield NADP. Mutations in this gene result in 2,4-dienoyl-CoA reductase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

NADK2 Products(4)

mRNA	Protein	Name
NM_001085411.3	NP_001078880.1	NAD kinase 2, mitochondrial isoform 1
NM_001287340.2	NP_001274269.1	NAD kinase 2, mitochondrial isoform 2
NM_001287341.2	NP_001274270.1	NAD kinase 2, mitochondrial isoform 3
NM_153013.5	NP_694558.1	NAD kinase 2, mitochondrial isoform 2

NADK2 Protein Structure

NAD_kinase

0
100
200
300
400
442 a.a.

Protein Preferred Names

Protein Names

NAD kinase 2, mitochondrial

NAD kinase domain-containing protein 1, mitochondrial

Related Diseases

Diseases

Alias

2,4-Dienoyl-Coa Reductase Deficiency

Progressive Encephalopathy With Leukodystrophy Due To Decr Deficiency	DECRD
2,4-Alpha Dienoyl-Coa Reductase Deficiency	Dienoyl-Coa Reductase Deficiency
Decr Deficiency With Hyperlysinemia

Hyperlysinemia, Type I

Hyperlysinemia	Lysine Intolerance
Alpha-Aminoadipic Semialdehyde Synthase Deficiency	Lysine:Alpha-Ketoglutarate Reductase Deficiency
L-Lysine:Nad-Oxido-Reductase Deficiency	Lysine Alpha-Ketoglutarate Reductase Deficiency
Alpha-Aminoadipic Semialdehyde Deficiency Disease	Lysine Alpha-Ketoglutarate Reductase Deficiency Disease
Saccharopinuria	Hyperlysinemia Type I
Hyperlysinemias	L-Lysine Nad-Oxido-Reductase Deficiency
Familial Hyperlysinemia	Saccharopine Dehydrogenase Deficiency Disease
Hyperlysinemia, 1	HYPLYS1
Saccharopine Dehydrogenase Deficiency

Hyperprolinemia, Type I

Proline Oxidase Deficiency	Hyperprolinemia Type 1
HYRPRO1	Hpi
Hyperprolinemia Type I	Hyperprolinemia 1
Proline Dehydrogenase Deficiency

Hyperprolinemia, Type Ii

Hyperprolinemia Type 2	HYRPRO2
Hpii	1-Pyrroline-5-Carboxylate Dehydrogenase Deficiency
Hyperprolinemia Type Ii	1 Alpha Pyrroline-5-Carboxylate Dehydrogenase Deficiency
Type 2 Hyperprolinemia	Delta-1-Pyrroline-5-Carboxylate Dehydrogenase Deficiency
Hyperprolinemia 2

Fumarase Deficiency

Fumaric Aciduria	FMRD
Fumarate Hydratase Deficiency	Deficiency, Fumarase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09005	NADK2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NADK2	RGD	RGD:1306809
Macaca mulatta	NADK2	VGNC	VGNC:75029
Bos taurus	NADK2	VGNC	VGNC:31864
Felis catus	NADK2	VGNC	VGNC:63710
Mus musculus	NADK2	MGD	MGI:1915896

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