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CSPG4 - chondroitin sulfate proteoglycan 4 Gene

Also Known as NG2; MCSP; MCSPG; MSK16; CSPG4A; HMW-MAA; MEL-CSPG

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1464

About CSPG4

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,674,322-75,713,466 (from NCBI)

This gene has 1 transcript (splice variant) and 193 orthologues. Broad expression in fat (RPKM 18.8), placenta (RPKM 10.9) and 19 other tissues.

Summary

A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]

CSPG4 Products (1)

mRNA	Protein	Name
NM_001897.5	NP_001888.2	chondroitin sulfate proteoglycan 4 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein kinase binding	IPI IPI: Inferred from physical interaction	10587647	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10587647	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	10587647	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSPG4 Protein Structure

Laminin_G_1

Laminin_G_2

0
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800
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1600
2000
2322 a.a.

Protein Preferred Names	Protein Names
chondroitin sulfate proteoglycan 4	chondroitin sulfate proteoglycan 4 (melanoma-associated)

CSPG4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83476	NG2 Antibody (YA3221)	WB, IHC-P, FC	Human

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Demyelinating Disease	Demyelinating Diseases Demyelinating Disorder
Chordoma	CHDM Notochordoma Notochordal Sarcoma Chordoma, Susceptibility To Chordocarcinoma Chordoepithelioma
Acral Lentiginous Melanoma	Acral Lentiginous Melanoma, Malignant Malignant Acral Lentiginous Melanoma Alm Acral Lentiginous Malignant Melanoma Of Skin Palmar/Plantar Melanoma Subungual Melanoma Acral Lentiginous Malignant Melanoma
Ullrich Congenital Muscular Dystrophy 1	Ullrich Congenital Muscular Dystrophy Ullrich Disease Ucmd Ullrich Scleroatonic Muscular Dystrophy Scleroatonic Muscular Dystrophy UCMD1 Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 22 Lgmdr22 Muscular Dystrophy, Scleroatonic Late Onset Scleroatonic Familial Myopathy Congenital Muscular Dystrophy, Ullrich Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS26166	Cspg4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P11838	DOTA-TH10		/	Unkown
HY-RS03254	CSPG4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19673	Cspg4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CSPG4	RGD	RGD:619942
Mus musculus	CSPG4	MGD	MGI:2153093
Bos taurus	CSPG4	VGNC	VGNC:57158
Felis catus	CSPG4	VGNC	VGNC:61227
Macaca mulatta	CSPG4	VGNC	VGNC:71525
Canis familiaris	CSPG4	VGNC	VGNC:59107
Others	CSPG4	NCBI