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  5. NG2 Antibody (YA3221)

NG2 Antibody (YA3221) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NG2.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Descripciòn

Descripciòn

NG2 Antibody (YA3221) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NG2.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Peso molecular
Predicted band size: 251 kDa;
Observed band size: 251 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human NG2 aa2250-2322/2322.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
FC
FC: Flow Cytometry
1:50-1:100
Sensitivity Endogenous Pureza Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Envío

Shipping with blue ice.
Background
Function：Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Also functions as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades
Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Extracellular side; Apical cell membrane; Single-pass type I membrane protein; Extracellular side; Cell projection, lamellipodium membrane; Single-pass type I membrane protein; Extracellular side; Cell surface
Expression：
Tissue_specificity:Detected in fibroblasts (at protein level) (PubMed:36213313) . Detected in placenta (at protein level) (PubMed:32337544) . Detected in malignant melanoma cells
Subunit：Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA.
RRID
Database

Entrez Gene: 1464 Human

SwissProt: Q6UVK1 Human

OMIM: 601172 Human

Research Field

Neuroscience
Synonyms
NG2; MCSP; MCSPG; MSK16; HMW-MAA; MEL-CSPG
Documentación
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

NG2 Antibody (YA3221) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nombre del producto:
NG2 Antibody (YA3221)
Cat. No.:
HY-P83476
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SAFETY DATA SHEET (SDS)

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