CSTA - cystatin A Gene

Also Known as AREI; PSS4; STF1; STFA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1475

About CSTA

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,325,248-122,341,969 (from NCBI)

This gene has 2 transcripts (splice variants), 208 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in esophagus (RPKM 1149.9), skin (RPKM 100.5) and 1 other tissue.

Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine Protease Inhibitors, while Others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for Cancer. [provided by RefSeq, Jul 2008]

CSTA Products (1)

mRNA	Protein	Name
NM_005213.4	NP_005204.1	cystatin-A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables cysteine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	3488317	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	6203523	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11152132	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	21944047	GOA
involved in keratinocyte differentiation	IDA IDA: Inferred from direct assay	10908733	GOA
involved in negative regulation of peptidase activity	IDA IDA: Inferred from direct assay	6203523	GOA
involved in negative regulation of proteolysis	IDA IDA: Inferred from direct assay	3488317	GOA
involved in peptide cross-linking	IDA IDA: Inferred from direct assay	10908733	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cornified envelope	IDA IDA: Inferred from direct assay	10908733	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21944047	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	3488317	GOA
part of peptidase inhibitor complex	IPI IPI: Inferred from physical interaction	20860624	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSTA Protein Structure

Cystatin

0
98 a.a.

Protein Preferred Names	Protein Names
cystatin-A	cystatin A (stefin A)

CSTA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	CSTA	P01040	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	CSTA	P01040	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	CSTA	P01040	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	CSTA	P01040	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	CSTA	P01040	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	CSTA	P01040	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	CSTA	P01040	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	CSTA	P01040	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	CSTA	P01040	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	CSTA	P01040	CTSB	Homo sapiens	P07858	Anti Tag CoIP	33961781
Intra	CSTA	P01040	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	CSTA	P01040	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	CSTA	P01040	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Cross	CSTA	P01040	papa1_carpa	Carica papaya	P00784	Fluorescence	11152132

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSTA Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P7868	Cystatin A/CSTA Protein, Human (His)	P01040 (I2-F98)	≥ 95%, as determined by reducing SDS-PAGE.

CSTA Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P83015	Cystatin A Antibody (YA2760)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Peeling Skin Syndrome 4	PSS4 Arei Exfoliative Ichthyosis, Autosomal Recessive Ichthyosis Bullosa Of Siemens-Like Ichthyosis, Exfoliative, Autosomal Recessive Exfoliative Ichthyosis Autosomal Recessive Ibs-Like Ichthyosis, Exfoliative, Autosomal Recessive, Ichthyosis Bullosa Of Siemens-Like Skin, Peeling, Syndrome, Type 4 Exfoliative Ichthyosis, Autosomal Recessive, Ichthyosis Bullosa Of Siemens-Like
Peeling Skin Syndrome 2	Acral Peeling Skin Syndrome Peeling Skin Syndrome, Acral Type Apss PSS2 Acral Pss Acral Deciduous Skin Localized Pss Localized Deciduous Skin Peeling Skin Syndrome Type A Skin, Peeling, Syndrome, Type 2
Exfoliative Ichthyosis	Ichthyosis Exfoliativa Autosomal Recessive Exfoliative Ichthyosis
Peeling Skin Syndrome	Deciduous Skin Familial Continuous Skin Peeling Syndrome Idiopathic Deciduous Skin Keratosis Exfoliativa Congenita Pss Peeling Skin Disease Skin Peeling Syndrome Familial Continuous Skin Peeling Keratolysis Exfoliativa Congenita Exfoliation Syndrome Keratolysis Exfoliativa
Ichthyosis Bullosa Of Siemens	IBS Ichthyosis, Bullous Type Bullous Type Of Ichthyosis Ichthyosis Bullous Type
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Cerebral Amyloid Angiopathy, Cst3-Related	Cerebral Amyloid Angiopathy Hereditary Cerebral Hemorrhage With Amyloidosis Hchwa Hereditary Cystatin C Amyloid Angiopathy Cerebral Amyloid Angiopathy, Familial Amyloidosis, Cerebroarterial, Icelandic Type Amyloidosis Vi Cerebral Hemorrhage, Hereditary, With Amyloidosis Cst3-Related Cerebral Amyloid Angiopathy Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant Caa, Familial Cerebral Amyloid Angiopathy, Genetic Acys Amyloidosis Cst3-Related Amyloidosis Cystatin Amyloidosis Hchwa, Icelandic Type Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type Amyloidosis 6 AMYL6 Acys Caa Cerebral Amyloid Angiopathy Cst3-Related Cerebroarterial Amyloidosis Icelandic Type Cystatin C Amyloidosis Hccaa Hchwai Hchwa-I Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type Cerebral Amyloid Angiopathy Familial Angiopathy, Amyloid, Cerebral, Cst3-Related Hereditary Cerebral Amyloid Angiopathy, Icelandic Type Familial Cerebral Amyloid Angiopathy Cerebral Amyloid Angiopathy, Hereditary
Psoriasis
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-181126	G194-0712	Activator	99.82%	Unkown
HY-RS03271	CSTA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24206	Csta Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CSTA	VGNC	VGNC:97176
Rattus norvegicus	CSTA	RGD	RGD:1309603
Canis familiaris	CSTA	VGNC	VGNC:39681
Bos taurus	CSTA	VGNC	VGNC:27779
Macaca mulatta	CSTA	VGNC	VGNC:71533
Others	CSTA	NCBI