SLC30A7 - solute carrier family 30 member 7 Gene

Also Known as ZNT7; ZnT-7; ZnTL2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 148867

About SLC30A7

Cytogenetic location: 1p21.2 Genomic coordinates (GRCh38): 1:100,896,090-100,996,078 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 8 paralogues. Ubiquitous expression in appendix (RPKM 3.9), thyroid (RPKM 3.9) and 25 other tissues.

Summary

Zinc functions as a cofactor for numerous Enzymes, nuclear factors, and Hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]

SLC30A7 Products (2)

mRNA Protein Name
NM_001144884.2 NP_001138356.1 zinc transporter 7
NM_133496.5 NP_598003.2 zinc transporter 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
15994300 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
15525635 GOA
Biological Process GO Annotation Evidence References Source
involved in zinc ion import into Golgi lumen IDA
IDA: Inferred from direct assay
15525635 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
17349999 GOA
located in Golgi cis cisterna membrane IDA
IDA: Inferred from direct assay
15525635 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17349999 GOA
located in vesicle IDA
IDA: Inferred from direct assay
17349999 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC30A7 Protein Structure

Cation_efflux

Cation_efflux: Cation efflux family (38 - 374)

  • 0
  • 100
  • 200
  • 300
  • 376 a.a.
Protein Preferred Names Protein Names

zinc transporter 7

  • solute carrier family 30 (zinc transporter), member 7

SLC30A7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC30A7 Q8NEW0 SLC30A7 Homo sapiens Q8NEW0
Anti Tag CoIP
15994300
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Joubert Syndrome 1

  • Joubert Syndrome

  • Jbts

  • Cerebellooculorenal Syndrome 1

  • JBTS1

  • Joubert-Boltshauser Syndrome

  • Cerebelloparenchymal Disorder Iv

  • Cpd4

  • Cors1

  • Joubert Syndrome And Related Disorders

  • Jsrd

  • Familial Aplasia Of The Vermis

  • Joubert Syndrome Related Disorders

  • Js

  • Cerebellar Vermis Agenesis

  • Cerebelloparenchymal Disorder 4

  • Agenesis Of Cerebellar Vermis

  • Cerebello-Oculo-Renal Syndrome

  • Cors

  • Joubert-Bolthauser Syndrome

  • Cpd Iv

  • Classic Joubert Syndrome

  • Joubert Syndrome Type A

  • Pure Joubert Syndrome

  • Cerebello-Oculo-Renal Syndrome 1

  • Joubert Syndrome-1

  • Joubert Syndrome, Type 1

  • Joubert'S Syndrome
Acrodermatitis Enteropathica, Zinc-Deficiency Type

  • Acrodermatitis Enteropathica

  • AEZ

  • Enteropathica

  • Brandt Syndrome

  • Ae

  • Acrodermatitis Enteropathica Zinc Deficiency Type

  • Danbolt-Cross Syndrome

  • Acrodermatitis Enteropathica, Zinc Deficiency Type

  • Inherited Zinc Deficiency

  • Acrodermatitis Enteropathica, Zinc Deficiency

  • Danbolt-Closs Syndrome

  • Primary Zinc Malabsorption Syndrome
Mucinous Stomach Adenocarcinoma

  • Mucinous Adenocarcinoma Of The Stomach

  • Mucinous Gastric Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13185 SLC30A7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC30A7 MGD MGI:1913750
Felis catus SLC30A7 VGNC VGNC:65313
Canis familiaris SLC30A7 VGNC VGNC:46352
Macaca mulatta SLC30A7 VGNC VGNC:77514
Bos taurus SLC30A7 VGNC VGNC:34811
Rattus norvegicus SLC30A7 RGD RGD:1307873
Others SLC30A7 NCBI