TCF23 - transcription factor 23 Gene

Also Known as OUT; TCF-23; bHLHa24

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 150921

About TCF23

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,149,004-27,156,974 (from NCBI)

This gene has 2 transcripts (splice variants), 180 orthologues and 13 paralogues. Biased expression in endometrium (RPKM 12.5), ovary (RPKM 9.5) and 2 other tissues.

Summary

The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in mouse have shown the encoded protein does not bind DNA but may negatively regulate Other basic helix-loop-helix factors via the formation of a functionally inactive heterodimeric complex. [provided by RefSeq, May 2010]

TCF23 Products (1)

mRNA	Protein	Name
NM_175769.3	NP_786951.1	transcription factor 23

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within decidualization	IMP IMP: Inferred from mutant phenotype	24571987	GOA
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24571987	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCF23 Protein Structure

HLH

0
100
200
214 a.a.

Protein Preferred Names	Protein Names
transcription factor 23	class A basic helix-loop-helix protein 24

TCF23 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TCF23	Q7RTU1	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	TCF23	Q7RTU1	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	TCF23	Q7RTU1	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	TCF23	Q7RTU1	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	TCF23	Q7RTU1	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Retinal Arteries, Tortuosity Of	Retinal Arterial Tortuosity Retinal Hemorrhage With Vascular Tortuosity RATOR Tortuosity Of Retinal Arteries Retinal Arteriolar Tortuosity Familial Isolated Retinal Arterial Tortuosity Tortuosity, Arteries, Retinal
Ras-Associated Autoimmune Leukoproliferative Disorder	RALD Autoimmune Lymphoproliferative Syndrome Type 4 Alps4 Autoimmune Lymphoproliferative Syndrome, Type Iv Ras-Associated Autoimmune Leukoproliferative Disease Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic Alps Type 4 Alps Type Iv Autoimmune Lymphoproliferative Syndrome Type Iv Autoimmune Lymphoproliferative Syndrome 4
Fanconi Anemia, Complementation Group E	Fanconi Anemia Complementation Group E FANCE Face Faces Syndrome
Western Equine Encephalitis	Western Equine Encephalomyelitis Wee Encephalomyelitis, Western Equine Western Equine Encephalitis Virus Infection Wee - [Western Equine Encephalitis] Western Equine Encephalitis Virus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14304	TCF23 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TCF23	VGNC	VGNC:35691
Felis catus	TCF23	VGNC	VGNC:81235
Macaca mulatta	TCF23	VGNC	VGNC:79156
Rattus norvegicus	TCF23	RGD	RGD:1586500
Canis familiaris	TCF23	VGNC	VGNC:47194
Mus musculus	TCF23	MGD	MGI:1934960
Others	TCF23	NCBI