CELSR2 - cadherin EGF LAG seven-pass G-type receptor 2 Gene

Homo sapiens

Also known as EGFL2; MEGF3; ADGRC2; CDHF10; Flamingo1

Gene ID: 1952 | Gene type: protein coding

About CELSR2

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,249,539-109,275,751 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 6 paralogues. Biased expression in brain (RPKM 19.7), skin (RPKM 15.6) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo Cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]

CELSR2 Products(1)

mRNA	Protein	Name
NM_001408.3	NP_001399.1	cadherin EGF LAG seven-pass G-type receptor 2 precursor

CELSR2 Protein Structure

Cadherin

Laminin_G_2

EGF

Laminin_G_2

Laminin_EGF

GPS

7tm_2

0
500
1000
1500
2000
2500
2923 a.a.

Protein Preferred Names

Protein Names

cadherin EGF LAG seven-pass G-type receptor 2

EGF-like protein 2

Related Diseases

Diseases

Alias

Orofaciodigital Syndrome Iii

Sugarman Syndrome	OFD3
Orofaciodigital Syndrome 3	Ofds Iii
Oral Facial Digital Syndrome Type 3	Oral-Facial-Digital Syndrome Type 3
Oral-Facial-Digital Syndrome, Type Iii	Ofd Syndrome 3
Ofds 3	Oral Facial Digital Syndrome 3
Orofaciodigital Syndrome Type 3

Tracheoesophageal Fistula With Or Without Esophageal Atresia

Esophageal Atresia With Or Without Tracheoesophageal Fistula

Esophageal Atresia

Tracheoesophageal Fistula	Congenital Atresia Of Esophagus
Congenital Imperforate Esophagus	Imperforate Esophagus
Oesophageal Atresia	Te Fistula
Tef	Tracheoesophageal Fistula With Or Without Esophageal Atresia

Congenital Hydrocephalus

Hydrocephalus	Hydrocephalus Adverse Event
Hydrocephalus, Nonsyndromic, Autosomal Recessive 1	Hydrocephalus In Newborn
Congenital Hydrocephaly

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive	Hydrocephalus, X-Linked
Hydrocephalus Adverse Event	Hydrocephaly Nos

Scoliosis

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-W019870	Glufosinate ammonium	≥98.0%	Unkown
HY-RS02466	CELSR2 Human Pre-designed siRNA Set A	/	Unkown
HY-W019870A	Glufosinate	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CELSR2	VGNC	VGNC:39098
Rattus norvegicus	CELSR2	RGD	RGD:69237
Bos taurus	CELSR2	VGNC	VGNC:27170
Macaca mulatta	CELSR2	VGNC	VGNC:71149
Mus musculus	CELSR2	MGD	MGI:1858235
Felis catus	CELSR2	VGNC	VGNC:60749
Others	CELSR2	NCBI

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