EGR4 - early growth response 4 Gene
Also Known as AT133; NGFIC; NGFI-C; PAT133
Species: Homo sapiens
About EGR4
This gene has 2 transcripts (splice variants), 283 orthologues and 4 paralogues. Biased expression in brain (RPKM 3.5) and testis (RPKM 1.6).
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
EGR4 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001965.4 | NP_001956.4 | early growth response protein 4 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables DNA-binding transcription activator activity, RNA polymerase II-specific |
IDA
IDA: Inferred from direct assay
|
12560487 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| enables sequence-specific DNA binding |
IDA
IDA: Inferred from direct assay
|
23332764 | GOA |
| enables sequence-specific double-stranded DNA binding |
IDA
IDA: Inferred from direct assay
|
28473536 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of transcription by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
12560487 | GOA |
EGR4 Protein Structure
zf-H2C2_2: Zinc-finger double domain (500 - 523)
zf-H2C2_2: Zinc-finger double domain (527 - 551)
- 0
- 100
- 200
- 300
- 400
- 500
- 589 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
early growth response protein 4 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Schizophrenia 19 |
|
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| Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive |
|
|
| Cryptorchidism, Unilateral Or Bilateral |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | EGR4 | VGNC | VGNC:40243 |
| Rattus norvegicus | EGR4 | RGD | RGD:2546 |
| Mus musculus | EGR4 | MGD | MGI:99252 |
| Bos taurus | EGR4 | VGNC | VGNC:28369 |
| Macaca mulatta | EGR4 | VGNC | VGNC:106151 |
| Others | EGR4 | NCBI |