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CADM4 - cell adhesion molecule 4 Gene

Also Known as NECL4; TSLL2; IGSF4C; Necl-4; synCAM4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 199731

About CADM4

Cytogenetic location: 19q13.31 Genomic coordinates (GRCh38): 19:43,622,368-43,641,984 (from NCBI)

This gene has 2 transcripts (splice variants), 191 orthologues and 14 paralogues. Biased expression in brain (RPKM 59.7), kidney (RPKM 14.7) and 8 other tissues.

Summary

Enables vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including negative regulation of protein phosphorylation; regulation of Rac protein signal transduction; and regulation of wound healing. Located in cell leading edge and cell-cell contact zone. [provided by Alliance of Genome Resources, Apr 2022]

CADM4 Products (1)

mRNA	Protein	Name
NM_145296.2	NP_660339.1	cell adhesion molecule 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	33961781	GOA
enables vascular endothelial growth factor receptor 2 binding	IPI IPI: Inferred from physical interaction	25893857	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	23611113	GOA
involved in negative regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	23611113	GOA
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	25893857	GOA
involved in regulation of Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	25893857	GOA
involved in regulation of cell motility	IMP IMP: Inferred from mutant phenotype	25893857	GOA
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	25893857	GOA
involved in regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	25893857	GOA
involved in regulation of wound healing	IMP IMP: Inferred from mutant phenotype	25893857	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell leading edge	IDA IDA: Inferred from direct assay	25893857	GOA
located in cell-cell contact zone	IDA IDA: Inferred from direct assay	25893857	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CADM4 Protein Structure

V-set

C2-set_2

Ig_2

0
100
200
300
388 a.a.

Protein Preferred Names	Protein Names
cell adhesion molecule 4	TSLC1-like 2

Recombinant CADM4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76187	CADM4/IGSF4C Protein, Human (HEK293, His)	Q8NFZ8 (P21-Y323)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76188	CADM4/IGSF4C Protein, Human (HEK293, Fc)	Q8NFZ8 (P21-Y323)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Ciliary Dyskinesia, Primary, 22	Primary Ciliary Dyskinesia 22 CILD22 Primary Ciliary Dyskinesia 22 With Or Without Situs Inversus Ciliary Dyskinesia, Primary, 22, With Or Without Situs Inversus Dyskinesia, Ciliary, Primary, 22
Spondylometaphyseal Dysplasia With Cone-Rod Dystrophy	Spondylometaphyseal Dysplasia-Cone-Rod Dystrophy Syndrome SMDCRD Smd-Crd Dysplasia, Spondylometaphyseal, With Cone-Rod Dystrophy
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive	Charcot-Marie-Tooth Disease Type 4 Charcot-Marie-Tooth Disease Type 4e Hereditary Motor And Sensory Neuropathy Cmt4e CHN1 Hypomyelinating Neuropathy, Congenital, 1 Charcot-Marie-Tooth Neuropathy Type 4e Neuropathy, Congenital Hypomyelinating, 1 Ar-Cmt1 Autosomal Recessive Demyelinating Charcot-Marie-Tooth Cmt4 Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive Hypomyelination, Severe Congenital Charcot-Marie-Tooth Disease, Type 4e Charcot-Marie-Tooth Neuropathy, Type 4e Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy Autosomal Recessive Congenital Hypomyelinating Neuropathy Congenital Amyelinating Neuropathy Congenital Hypomyelinating Neuropathy Autosomal Recessive Neuropathy, Congenital Hypomyelinating Or Amyelinating Severe Congenital Hypomyelination Hereditary Sensory Motor Neuropathy Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive Neuropathy, Hypomyelinating, Congenital, Type 1 Neuropathy, Motor And Sensory, Hereditary Congenital Hypomyelinating Neuropathy Hereditary Motor And Sensory Neuropathies Hereditary Sensorimotor Neuropathy Hmsn - [Hereditary Motor And Sensory Neuropathy] Hsmn - [Hereditary Sensory And Motor Neuropathy] Hereditary Motor And Sensory Neuropathy, Types I-Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01822	CADM4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18378	Cadm4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24858	Cadm4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CADM4	VGNC	VGNC:53675
Mus musculus	CADM4	MGD	MGI:2449088
Macaca mulatta	CADM4	VGNC	VGNC:70681
Rattus norvegicus	CADM4	RGD	RGD:1304722
Bos taurus	CADM4	VGNC	VGNC:26697
Felis catus	CADM4	VGNC	VGNC:60315
Others	CADM4	NCBI