Six4 - sine oculis-related homeobox 4 Gene

Also Known as AREC3; TrexBF

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20474

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; positive regulation of morphogenesis of an epithelium; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including embryonic organ morphogenesis; myoblast migration; and thymus development. Located in cytoplasm and nucleus. Is expressed in several structures, including exocrine gland; nervous system; sensory organ; tongue; and urinary system. Orthologous to human SIX4 (SIX homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]

Six4 Products (3)

mRNA Protein Name
NM_001362272.2 NP_001349201.1 homeobox protein SIX4 isoform 2
NM_001409898.1 NP_001396827.1 homeobox protein SIX4 isoform 3
NM_011382.3 NP_035512.1 homeobox protein SIX4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
14966291 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15955062 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14966291 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15955062 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12215533 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8814301 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anatomical structure development IGI
IGI: Inferred from genetic interaction
16530750 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IGI
IGI: Inferred from genetic interaction
20515681 MGI
acts upstream of or within embryonic skeletal system morphogenesis IGI
IGI: Inferred from genetic interaction
15788460 MGI
involved in fungiform papilla morphogenesis IMP
IMP: Inferred from mutant phenotype
21978088 MGI
involved in generation of neurons IMP
IMP: Inferred from mutant phenotype
16938278 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
15788460 MGI
involved in male gonad development IMP
IMP: Inferred from mutant phenotype
23987514 MGI
involved in male sex determination IMP
IMP: Inferred from mutant phenotype
23987514 MGI
involved in male sex differentiation IMP
IMP: Inferred from mutant phenotype
23987514 MGI
involved in metanephric mesenchyme development IMP
IMP: Inferred from mutant phenotype
17300925 MGI
acts upstream of or within myoblast migration IGI
IGI: Inferred from genetic interaction
15788460 MGI
involved in myotome development IMP
IMP: Inferred from mutant phenotype
15788460 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15955062 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15788460 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
16938278 MGI
involved in negative regulation of satellite cell differentiation IMP
IMP: Inferred from mutant phenotype
20696153 MGI
involved in olfactory placode formation IMP
IMP: Inferred from mutant phenotype
19027001 MGI
involved in pharyngeal system development IMP
IMP: Inferred from mutant phenotype
16530750 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14966291 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15955062 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17300925 MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
17300925 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15955062 MGI
involved in positive regulation of ureteric bud formation IMP
IMP: Inferred from mutant phenotype
17300925 MGI
involved in protein localization to nucleus IDA
IDA: Inferred from direct assay
10490620 MGI
involved in regulation of branch elongation involved in ureteric bud branching IMP
IMP: Inferred from mutant phenotype
17300925 MGI
involved in regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
19027001 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
21884692 MGI
acts upstream of or within regulation of protein localization IGI
IGI: Inferred from genetic interaction
21884692 MGI
acts upstream of or within regulation of synaptic assembly at neuromuscular junction IGI
IGI: Inferred from genetic interaction
21884692 MGI
involved in sarcomere organization IMP
IMP: Inferred from mutant phenotype
21884692 MGI
involved in skeletal muscle fiber differentiation IMP
IMP: Inferred from mutant phenotype
21884692 MGI
acts upstream of or within skeletal muscle tissue development IGI
IGI: Inferred from genetic interaction
15788460 MGI
involved in skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
17592144 MGI
acts upstream of or within thymus development IGI
IGI: Inferred from genetic interaction
16530750 MGI
involved in tongue development IMP
IMP: Inferred from mutant phenotype
21978088 MGI
involved in trigeminal ganglion development IMP
IMP: Inferred from mutant phenotype
16938278 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9990334 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8814301 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein SIX4

  • sine oculis-related homeobox 4 homolog

  • skeletal muscle-specific ARE-binding protein AREC3

Six4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Six4 Q61321 Kdm6a Mus musculus O70546
Anti Bait CoIP
20300060
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12961 SIX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21434 Six4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27952 Six4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Six4 NCBI NCBI:51804