Ugcg - UDP-glucose ceramide glucosyltransferase Gene

Also Known as Ugcgl; Epcs21; GlcT-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22234

About Ugcg

Chromosome 4: 59,189,257-59,222,833 forward strand.GRCm39:CM000997.3

This gene has 4 transcripts (splice variants), 212 orthologues and is associated with 13 phenotypes. Ubiquitous expression in CNS E18 (RPKM 2.2), whole brain E14.5 (RPKM 18.2) and 28 other tissues.

Summary

Enables ceramide glucosyltransferase activity. Involved in several processes, including cornified envelope assembly; glucosylceramide biosynthetic process; and skin development. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in several structures, including blastocyst; brain; early embryo; liver; and oocyte. Orthologous to human UGCG (UDP-glucose ceramide glucosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Ugcg Products (1)

mRNA Protein Name
NM_011673.3 NP_035803.1 ceramide glucosyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ceramide glucosyltransferase activity IMP
IMP: Inferred from mutant phenotype
10430909 MGI
Biological Process GO Annotation Evidence References Source
involved in cell differentiation IMP
IMP: Inferred from mutant phenotype
10430909 MGI
involved in cornified envelope assembly IMP
IMP: Inferred from mutant phenotype
23748427 MGI
involved in establishment of skin barrier IMP
IMP: Inferred from mutant phenotype
17145749 MGI
involved in glucosylceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
10430909 MGI
involved in intestinal lipid absorption IMP
IMP: Inferred from mutant phenotype
22851168 MGI
involved in keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
23748427 MGI
involved in leptin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
23554574 MGI
involved in neuron development IMP
IMP: Inferred from mutant phenotype
16109770 MGI
involved in protein lipidation IMP
IMP: Inferred from mutant phenotype
23748427 MGI
involved in regulation of signal transduction IMP
IMP: Inferred from mutant phenotype
23554574 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ugcg Protein Structure

Glucosylceramide_synthase

Glucosylceramide_synthase: cd02520 (50 - 279)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
Protein Preferred Names Protein Names

ceramide glucosyltransferase

  • GCS

  • UDP-glucose:N-acylsphingosine D-glucosyltransferase

  • ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 21

  • glucosylceramide synthase

  • glycosylceramide synthase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-132596 Tivanisiran Inhibitor 97.48% Phase 3
HY-148100 Emapticap pegol Inhibitor 91.38% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15419 UGCG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15420 Ugcg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15421 Ugcg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ugcg NCBI NCBI:7357