GPC5 - glypican 5 Gene
Species: Homo sapiens
About GPC5
This gene has 4 transcripts (splice variants), 189 orthologues, 5 paralogues and is associated with 83 phenotypes. Biased expression in brain (RPKM 1.8), testis (RPKM 1.4) and 7 other tissues.
Summary
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]
GPC5 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_004466.6 | NP_004457.1 | glypican-5 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
30282023 | GOA |
GPC5 Protein Structure
Glypican: Glypican (11 - 572)
- 0
- 100
- 200
- 300
- 400
- 500
- 572 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
glypican-5 |
|
GPC5 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
GPC5 | P78333 | MAGEC3 | Homo sapiens | Q8TD91-2 | 32814053 | |
|
Intra
|
GPC5 | P78333 | MAGEC3 | Homo sapiens | Q8TD91-2 | 32814053 | |
|
Intra
|
GPC5 | P78333 | MAGEC3 | Homo sapiens | Q8TD91-2 | 32814053 | |
|
Intra
|
GPC5 | P78333 | BOD1 | Homo sapiens | Q96IK1-2 | 32814053 | |
|
Intra
|
GPC5 | P78333 | BOD1 | Homo sapiens | Q96IK1-2 | 32814053 | |
|
Intra
|
GPC5 | P78333 | BOD1 | Homo sapiens | Q96IK1-2 | 32814053 | |
|
Intra
|
GPC5 | P78333 | FAM117B | Homo sapiens | Q6P1L5 | 32814053 | |
|
Intra
|
GPC5 | P78333 | FAM117B | Homo sapiens | Q6P1L5 | 32814053 | |
|
Intra
|
GPC5 | P78333 | FAM117B | Homo sapiens | Q6P1L5 | 32814053 | |
|
Intra
|
GPC5 | P78333 | RYBP | Homo sapiens | Q8N488 | 32814053 | |
|
Intra
|
GPC5 | P78333 | RYBP | Homo sapiens | Q8N488 | 32814053 | |
|
Intra
|
GPC5 | P78333 | RYBP | Homo sapiens | Q8N488 | 32814053 |
Recombinant GPC5 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P73079 | Glypican-5/GPC5 Protein, Human (sf9, His) | P78333/NP_004457.1 (E25-T554) | ≥ 90%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Omodysplasia |
|
|
| Nephrotic Syndrome |
|
|
| Keipert Syndrome |
|
|
| Simpson-Golabi-Behmel Syndrome, Type 1 |
|
|
| Hereditary Multiple Exostoses |
|
|
| Tetralogy Of Fallot |
|
|
| Feingold Syndrome 1 |
|
|
| Hepatocellular Carcinoma |
|
|
| Rhabdomyosarcoma |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | GPC5 | RGD | RGD:1308835 |
| Canis familiaris | GPC5 | VGNC | VGNC:49903 |
| Macaca mulatta | GPC5 | VGNC | VGNC:73119 |
| Felis catus | GPC5 | VGNC | VGNC:102214 |
| Bos taurus | GPC5 | VGNC | VGNC:29527 |
| Mus musculus | GPC5 | MGD | MGI:1194894 |
| Others | GPC5 | NCBI |