GPC5 - glypican 5 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2262

About GPC5

Cytogenetic location: 13q31.3 Genomic coordinates (GRCh38): 13:91,398,621-92,867,237 (from NCBI)

This gene has 4 transcripts (splice variants), 189 orthologues, 5 paralogues and is associated with 83 phenotypes. Biased expression in brain (RPKM 1.8), testis (RPKM 1.4) and 7 other tissues.

Summary

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]

GPC5 Products (1)

mRNA Protein Name
NM_004466.6 NP_004457.1 glypican-5 precursor
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30282023 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPC5 Protein Structure

Glypican

Glypican: Glypican (11 - 572)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 572 a.a.
Protein Preferred Names Protein Names

glypican-5

  • bA93M14.1

GPC5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPC5 P78333 MAGEC3 Homo sapiens Q8TD91-2 32814053
Intra
GPC5 P78333 MAGEC3 Homo sapiens Q8TD91-2 32814053
Intra
GPC5 P78333 MAGEC3 Homo sapiens Q8TD91-2 32814053
Intra
GPC5 P78333 BOD1 Homo sapiens Q96IK1-2 32814053
Intra
GPC5 P78333 BOD1 Homo sapiens Q96IK1-2 32814053
Intra
GPC5 P78333 BOD1 Homo sapiens Q96IK1-2 32814053
Intra
GPC5 P78333 FAM117B Homo sapiens Q6P1L5 32814053
Intra
GPC5 P78333 FAM117B Homo sapiens Q6P1L5 32814053
Intra
GPC5 P78333 FAM117B Homo sapiens Q6P1L5 32814053
Intra
GPC5 P78333 RYBP Homo sapiens Q8N488 32814053
Intra
GPC5 P78333 RYBP Homo sapiens Q8N488 32814053
Intra
GPC5 P78333 RYBP Homo sapiens Q8N488 32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GPC5 Proteins

Cat. No. Product Name Accession Purity
HY-P73079 Glypican-5/GPC5 Protein, Human (sf9, His) P78333/NP_004457.1 (E25-T554) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Omodysplasia
  • Omodysplasia Type 1

  • Omodysplasia 2

Nephrotic Syndrome
  • Finnish Congenital Nephrotic Syndrome

  • Ns - [Nephrotic Syndrome]

  • Nephrosis Syndrome

  • Nephrosis Nos

  • Glomerular Lesion Nephrosis

Keipert Syndrome
  • Nasodigitoacoustic Syndrome

  • KPTS

  • Nasodigitoacoustic Syndrome, Formerly

Simpson-Golabi-Behmel Syndrome, Type 1
  • Simpson-Golabi-Behmel Syndrome Type 1

  • Simpson-Golabi-Behmel Syndrome

  • SGBS1

  • Golabi-Rosen Syndrome

  • Simpson Dysmorphia Syndrome

  • Sgbs

  • Bulldog Syndrome

  • Dgsx

  • Sdys

  • Dysplasia Gigantism Syndrome, X-Linked

  • X-Linked Dysplasia Gigantism Syndrome

  • Dgsx Golabi-Rosen Syndrome

  • Sara Angers Syndrome

  • Sgb Syndrome

  • Mental Retardation-Overgrowth Syndrome

  • Simpson Dysplasia Syndrome

  • Simpson Syndrome

  • Simpson-Golabi-Behmel Syndrome 1

  • Dysplasia Gigantism Syndrome X-Linked

Hereditary Multiple Exostoses
  • Multiple Congenital Exostosis

  • Hereditary Multiple Exostoses 1

  • Hereditary Multiple Exostoses 2

  • Hereditary Multiple Exostoses 3

  • Multiple Exostosis Syndromes

  • Multiple Ostechondromas

  • Osteochondromatosis Syndrome

  • Exostoses Multiple Hereditary

  • Exostoses, Multiple Hereditary

Tetralogy Of Fallot
  • TOF

  • Fallot Tetralogy

  • Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

  • Tetrad Of Fallot

  • Fallot Tetrad

  • Fallot Disease

  • Fallot Complex

  • Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

  • Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

  • Interventricular Septal Defect, In Tetralogy Of Fallot

  • Ventricular Septal Defect With Obstructed Right Ventricular Outflow

  • Tof - [Tetralogy Of Fallot]

  • Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

  • Pulmonary Atresia, Ventricular Septal Defect And Mapcas

  • Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Feingold Syndrome 1
  • Feingold Syndrome

  • Oculodigitoesophagoduodenal Syndrome

  • Oded Syndrome

  • Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome

  • Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum

  • FGLDS1

  • Mmt Syndrome

  • Brunner-Winter Syndrome

  • Feingold Syndrome Type 1

  • Oded

  • Moded

  • Fglds

  • Microcephaly-Digital Anomalies-Normal Intelligence Syndrome

  • Moded Syndrome

  • Oculo-Digito-Esophageal-Duodenal Syndrome

  • Microcephaly, Mental Retardation, And Tracheoesophageal Fistula Syndrome

  • Microcephaly And Digital Abnormalities With Normal Intelligence

  • Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus, Or Duodenum

  • Microcephaly-Mesobrachyphalangy-Tracheoesophageal Fistula Syndrome

  • Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome

  • Oculo-Digito-Esophagoduodental Syndrome

  • Fs

  • Mmt

  • Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome

  • Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome

  • Brunner-Winter Syndrome Type 1

  • Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum Type 1

  • Fs1

  • Mmt Type 1

  • Moded Syndrome Type 1

  • Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Type 1

  • Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Type 1

  • Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome Type 1

  • Oded Syndrome Type 1

  • Oculo-Digito-Esophageal-Duodenal Syndrome Type 1

  • Feingold Syndrome, Type 1

Hepatocellular Carcinoma
  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour

Rhabdomyosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GPC5 RGD RGD:1308835
Canis familiaris GPC5 VGNC VGNC:49903
Macaca mulatta GPC5 VGNC VGNC:73119
Felis catus GPC5 VGNC VGNC:102214
Bos taurus GPC5 VGNC VGNC:29527
Mus musculus GPC5 MGD MGI:1194894
Others GPC5 NCBI