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ADGRL1 - adhesion G protein-coupled receptor L1 Gene

Also Known as CL1; LEC2; CIRL1; LPHN1; DEDBANP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22859

About ADGRL1

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,147,743-14,206,169 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 211 orthologues and 42 paralogues. Broad expression in brain (RPKM 19.5), fat (RPKM 7.9) and 22 other tissues.

Summary

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/Calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

ADGRL1 Products (2)

mRNA	Protein	Name
NM_001008701.3	NP_001008701.1	adhesion G protein-coupled receptor L1 isoform 1 precursor
NM_014921.5	NP_055736.2	adhesion G protein-coupled receptor L1 isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21078624	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRL1 Protein Structure

Gal_Lectin

OLF

HRM

GPS

7tm_2

Latrophilin

0
300
600
900
1200
1474 a.a.

Protein Preferred Names	Protein Names
adhesion G protein-coupled receptor L1	CIRL-1

Related Diseases

Diseases	Alias
Developmental Delay, Behavioral Abnormalities, And Neuropsychiatric Disorders	DEDBANP
Specific Learning Disability	Specific Learning Difficulty Specific Learning Disorder
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Loiasis	Loa Loa Filariasis Mansonelliasis African Eye Worm Mansonella Perstans Infections Mansonellosis Eye Worm Disease Of Africa Loa Loa Infestation African Eyeworm Disease Calabar Swelling
Polymicrogyria, Bilateral Frontoparietal	Bilateral Frontoparietal Polymicrogyria BFPP Cerebellar Ataxia With Neuronal Migration Defect
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00361	ADGRL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-184118	ADGRL1-IN-1	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ADGRL1	VGNC	VGNC:59638
Mus musculus	ADGRL1	MGD	MGI:1929461
Rattus norvegicus	ADGRL1	RGD	RGD:620768
Canis familiaris	ADGRL1	VGNC	VGNC:37650
Macaca mulatta	ADGRL1	VGNC	VGNC:69658
Bos taurus	ADGRL1	VGNC	VGNC:25671
Others	ADGRL1	NCBI