ADGRL1 - adhesion G protein-coupled receptor L1 Gene

Homo sapiens

Also known as CL1; LEC2; CIRL1; LPHN1; DEDBANP

Gene ID: 22859 | Gene type: protein coding

About ADGRL1

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,147,743-14,206,169 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 211 orthologues and 42 paralogues. Broad expression in brain (RPKM 19.5), fat (RPKM 7.9) and 22 other tissues.

Summary

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/Calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

ADGRL1 Products(2)

mRNA	Protein	Name
NM_001008701.3	NP_001008701.1	adhesion G protein-coupled receptor L1 isoform 1 precursor
NM_014921.5	NP_055736.2	adhesion G protein-coupled receptor L1 isoform 2 precursor

ADGRL1 Protein Structure

Gal_Lectin

OLF

HRM

GPS

7tm_2

Latrophilin

0
300
600
900
1200
1474 a.a.

Protein Preferred Names

Protein Names

adhesion G protein-coupled receptor L1

CIRL-1

Related Diseases

Diseases

Alias

Developmental Delay, Behavioral Abnormalities, And Neuropsychiatric Disorders

DEDBANP

Specific Learning Disability

Specific Learning Difficulty

Specific Learning Disorder

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Loiasis

Loa Loa Filariasis	Mansonelliasis
African Eye Worm	Mansonella Perstans Infections
Mansonellosis	Eye Worm Disease Of Africa
Loa Loa Infestation	African Eyeworm Disease
Calabar Swelling

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria	BFPP
Cerebellar Ataxia With Neuronal Migration Defect

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00361	ADGRL1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ADGRL1	VGNC	VGNC:59638
Mus musculus	ADGRL1	MGD	MGI:1929461
Rattus norvegicus	ADGRL1	RGD	RGD:620768
Canis familiaris	ADGRL1	VGNC	VGNC:37650
Macaca mulatta	ADGRL1	VGNC	VGNC:69658
Bos taurus	ADGRL1	VGNC	VGNC:25671

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