2. PI3K/Akt/mTOR Stem Cell/Wnt JAK/STAT Signaling
  3. GSK-3 STAT
  4. ADGRL1-IN-1

ADGRL1-IN-1 is a ADGRL1 inhibitor. ADGRL1-IN-1 activates the GSK3β-STAT1 signaling axis. ADGRL1-IN-1 induces anti-tumor immunity in a CT26 colorectal cancer mouse model. ADGRL1-IN-1 can be used in studies related to colorectal cancer.

For research use only. We do not sell to patients.

ADGRL1-IN-1

ADGRL1-IN-1 Chemical Structure

CAS No. : 693829-95-7

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ADGRL1-IN-1 Related Antibodies

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Description

ADGRL1-IN-1 is a ADGRL1 inhibitor. ADGRL1-IN-1 activates the GSK3β-STAT1 signaling axis. ADGRL1-IN-1 induces anti-tumor immunity in a CT26 colorectal cancer mouse model. ADGRL1-IN-1 can be used in studies related to colorectal cancer[1].

IC50 & Target[1]

GSK-3β

 

STAT1

 

In Vitro

ADGRL1-IN-1 (Compound 2) (15 mM) binds directly to ADGRL1 in CT26 cells, as evidenced by its ability to protect the receptor from protease degradation at a concentration of 15 mM[1].
ADGRL1-IN-1 activates the GSK3β-STAT1 axis in CT26 cells and induces BMDC activation via factors secreted by CT26 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ADGRL1-IN-1 Related Antibodies
In Vivo

ADGRL1-IN-1 elicits robust anti-tumor efficacy in BALB/c mice bearing CT26 colorectal cancer xenografts, reducing tumor growth and enhancing infiltration and activation of CD8+ T cells and cDC1s[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

368.15

Formula

C16H9BrF3NO
CAS No.
SMILES

FC(C1=CN=C(OC2=CC=C3C=CC=CC3=C2Br)C=C1)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ADGRL1-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADGRL1-IN-1693829-95-7GSK-3STATGlycogen synthase kinase-3Glycogen synthase kinase 3colorectal cancertumor cellsCD8+ T cellsADGRL1GAIN domainGSK3β-STAT1 axisdendritic cellCT26 cellscDC1sBALB/c miceInhibitorinhibitorinhibit

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