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Cat. No.: HY-184118

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ADGRL1-IN-1

ADGRL1-IN-1 is a ADGRL1 inhibitor. ADGRL1-IN-1 activates the GSK3β-STAT1 signaling axis. ADGRL1-IN-1 induces anti-tumor immunity in a CT26 colorectal cancer mouse model. ADGRL1-IN-1 can be used in studies related to colorectal cancer.

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CAS No.: 693829-95-7
Formule: C₁₆H₉BrF₃NO
Masse moléculaire:368.15

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Please store the product under the recommended conditions in the Certificate of Analysis.

ADGRL1-IN-1 Chemical Structure

CAS No.: 693829-95-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

IC₅₀ & Target^[1]

GSK-3β

STAT1

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In Vitro

ADGRL1-IN-1 (Compound 2) (15 mM) binds directly to ADGRL1 in CT26 cells, as evidenced by its ability to protect the receptor from protease degradation at a concentration of 15 mM^[1].
ADGRL1-IN-1 activates the GSK3β-STAT1 axis in CT26 cells and induces BMDC activation via factors secreted by CT26 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ADGRL1-IN-1 elicits robust anti-tumor efficacy in BALB/c mice bearing CT26 colorectal cancer xenografts, reducing tumor growth and enhancing infiltration and activation of CD8⁺ T cells and cDC1s^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 693829-95-7
Masse moléculaire 368.15
Formule C₁₆H₉BrF₃NO
SMILES

FC(C1=CN=C(OC2=CC=C3C=CC=CC3=C2Br)C=C1)(F)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Cheng G, et al. Ablation of the adhesion G protein-coupled receptor ADGRL1 activates anti-tumor immune response via cDC1-T cell hub formation. Cell Rep. Published online May 21, 2026. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
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ADGRL1-IN-1

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