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Cat. No.: HY-184118

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ADGRL1-IN-1

ADGRL1-IN-1 is a ADGRL1 inhibitor. ADGRL1-IN-1 activates the GSK3β-STAT1 signaling axis. ADGRL1-IN-1 induces anti-tumor immunity in a CT26 colorectal cancer mouse model. ADGRL1-IN-1 can be used in studies related to colorectal cancer.

For research use only. We do not sell to patients.

CAS No.: 693829-95-7
Formula: C₁₆H₉BrF₃NO
Molecular Weight:368.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ADGRL1-IN-1 Chemical Structure

CAS No.: 693829-95-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

IC₅₀ & Target^[1]

GSK-3β

STAT1

All GSK-3 Isoforms :

All STAT Isoforms :

In Vitro

ADGRL1-IN-1 (Compound 2) (15 mM) binds directly to ADGRL1 in CT26 cells, as evidenced by its ability to protect the receptor from protease degradation at a concentration of 15 mM^[1].
ADGRL1-IN-1 activates the GSK3β-STAT1 axis in CT26 cells and induces BMDC activation via factors secreted by CT26 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ADGRL1-IN-1 elicits robust anti-tumor efficacy in BALB/c mice bearing CT26 colorectal cancer xenografts, reducing tumor growth and enhancing infiltration and activation of CD8⁺ T cells and cDC1s^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 693829-95-7
Molecular Weight 368.15
Formula C₁₆H₉BrF₃NO
SMILES

FC(C1=CN=C(OC2=CC=C3C=CC=CC3=C2Br)C=C1)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cheng G, et al. Ablation of the adhesion G protein-coupled receptor ADGRL1 activates anti-tumor immune response via cDC1-T cell hub formation. Cell Rep. Published online May 21, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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ADGRL1-IN-1

All GSK-3 Isoforms

All STAT Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ADGRL1-IN-1 Related Classifications

HY-184118 Related Classifications