2. Gene
  3. CDK19 - cyclin dependent kinase 19 Gene

CDK19 - cyclin dependent kinase 19 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CDK11; DEE87; CDC2L6; EIEE87; bA346C16.3

Gene ID: 23097 | Gene type: protein coding

About CDK19

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:110,609,978-110,815,855 (from NCBI)

This gene has 8 transcripts (splice variants), 207 orthologues, 26 paralogues and is associated with 3 phenotypes. Broad expression in prostate (RPKM 16.5), brain (RPKM 8.7) and 23 other tissues.

Summary

This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

CDK19 Products(18)

mRNA Protein Name
XM_047418468.1 XP_047274424.1 cyclin-dependent kinase 19 isoform X2
XM_047418471.1 XP_047274427.1 cyclin-dependent kinase 19 isoform X7
NM_001300960.2 NP_001287889.1 cyclin-dependent kinase 19 isoform 2
XM_024446378.2 XP_024302146.1 cyclin-dependent kinase 19 isoform X2
NM_001300964.2 NP_001287893.1 cyclin-dependent kinase 19 isoform 3
NM_015076.5 NP_055891.1 cyclin-dependent kinase 19 isoform 1
XM_047418472.1 XP_047274428.1 cyclin-dependent kinase 19 isoform X7
XM_024446376.2 XP_024302144.2 cyclin-dependent kinase 19 isoform X2
XM_047418467.1 XP_047274423.1 cyclin-dependent kinase 19 isoform X2
XM_047418465.1 XP_047274421.1 cyclin-dependent kinase 19 isoform X1
XM_005266871.4 XP_005266928.1 cyclin-dependent kinase 19 isoform X5
XM_024446380.2 XP_024302148.1 cyclin-dependent kinase 19 isoform X2
XM_047418470.1 XP_047274426.1 cyclin-dependent kinase 19 isoform X6
XM_011535630.3 XP_011533932.2 cyclin-dependent kinase 19 isoform X4
NM_001300963.2 NP_001287892.1 cyclin-dependent kinase 19 isoform 3
XM_024446377.2 XP_024302145.1 cyclin-dependent kinase 19 isoform X2
XM_047418473.1 XP_047274429.1 cyclin-dependent kinase 19 isoform X8
XM_047418469.1 XP_047274425.1 cyclin-dependent kinase 19 isoform X3

CDK19 Protein Structure

Pkinase

Pkinase: Protein kinase domain (26 - 335)

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  • 502 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 19

CDC2-related protein kinase 6

CDK8-like cyclin-dependent kinase

cell division cycle 2-like 6 (CDK8-like)

cell division cycle 2-like protein kinase 6

cell division protein kinase 19

cyclin-dependent kinase (CDC2-like) 11

cyclin-dependent kinase 11

death-preventing kinase

Related Diseases

Diseases Alias
Non-Specific Early-Onset Epileptic Encephalopathy

Undetermined Early-Onset Epileptic Encephalopathy

Non-Specific Eoee

Undetermined Eoee
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome

Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

Syndactyly With Renal And Anogenital Malformations

STAR

Syndactyly, Telecanthus, Anogenital And Renal Malformations

Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Developmental And Epileptic Encephalopathy 87

DEE87

Epileptic Encephalopathy, Early Infantile, 87

Eiee87

Developmental And Epileptic Encephalopathy, 87

Early Infantile Epileptic Encephalopathy 87
Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic
Opitz-Kaveggia Syndrome

Fg Syndrome

Fgs1

Fgs

Keller Syndrome

OKS

Fg Syndrome 1

Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum

Fg Syndrome Type 1

Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum
Ohdo Syndrome

Young Simpson Syndrome

Ohdo Blepharophimosis Syndrome

Blepharophimosis Syndrome Ohdo Type

Blepharophimosis Intellectual Disability Syndromes

Bmrs

Blepharophimosis-Intellectual Disability Syndrome

Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth

Blepharophimosis Mental Retardation Syndromes

Sbbys Syndrome

Say Barber Biesecker Young-Simpson Syndrome

Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type

Bmrs, Ohdo Type

Blepharophimosis Syndrome, Ohdo Type

Ohdo-Madokoro-Sonoda Syndrome

Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type

Blepharophimosis - Intellectual Disability Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-126675A AS2863619 Inhibitor 99.94% Unkown
HY-111388A SEL120-34A monohydrochloride Inhibitor 98.69% Unkown
HY-19984 CCT-251921 Inhibitor 98.86% Unkown
HY-15681 Senexin A Inhibitor 99.85% Unkown
HY-122586 BRD6989 Inhibitor 99.56% Unkown
HY-111388B SEL120-34A hydrochloride Inhibitor 99.98% Unkown
HY-126675 AS2863619 free base Inhibitor 99.87% Unkown
HY-139875 JH-XVI-178 Inhibitor 98.16% Unkown
HY-101800 Senexin B Inhibitor 99.72% Unkown
HY-143889 Senexin C Inhibitor 98.06% Unkown
HY-111427 CDK8/19-IN-1 Inhibitor 98.03% Unkown
HY-111388 SEL120-34A Inhibitor / Unkown
HY-15681A Senexin A hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CDK19 VGNC VGNC:27122
Mus musculus CDK19 MGD MGI:1925584
Canis familiaris CDK19 VGNC VGNC:39050
Macaca mulatta CDK19 VGNC VGNC:71036
Rattus norvegicus CDK19 RGD RGD:1305435
Felis catus CDK19 VGNC VGNC:102398
Others CDK19 NCBI