CDK19 - cyclin dependent kinase 19 Gene

Also Known as CDK11; DEE87; CDC2L6; EIEE87; bA346C16.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23097

About CDK19

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:110,609,978-110,815,855 (from NCBI)

This gene has 8 transcripts (splice variants), 207 orthologues, 26 paralogues and is associated with 3 phenotypes. Broad expression in prostate (RPKM 16.5), brain (RPKM 8.7) and 23 other tissues.

Summary

This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

CDK19 Products (18)

mRNA Protein Name
XM_047418468.1 XP_047274424.1 cyclin-dependent kinase 19 isoform X2
XM_047418471.1 XP_047274427.1 cyclin-dependent kinase 19 isoform X7
NM_001300960.2 NP_001287889.1 cyclin-dependent kinase 19 isoform 2
XM_024446378.2 XP_024302146.1 cyclin-dependent kinase 19 isoform X2
NM_001300964.2 NP_001287893.1 cyclin-dependent kinase 19 isoform 3
NM_015076.5 NP_055891.1 cyclin-dependent kinase 19 isoform 1
XM_047418472.1 XP_047274428.1 cyclin-dependent kinase 19 isoform X7
XM_024446376.2 XP_024302144.2 cyclin-dependent kinase 19 isoform X2
XM_047418467.1 XP_047274423.1 cyclin-dependent kinase 19 isoform X2
XM_047418465.1 XP_047274421.1 cyclin-dependent kinase 19 isoform X1
XM_005266871.4 XP_005266928.1 cyclin-dependent kinase 19 isoform X5
XM_024446380.2 XP_024302148.1 cyclin-dependent kinase 19 isoform X2
XM_047418470.1 XP_047274426.1 cyclin-dependent kinase 19 isoform X6
XM_011535630.3 XP_011533932.2 cyclin-dependent kinase 19 isoform X4
NM_001300963.2 NP_001287892.1 cyclin-dependent kinase 19 isoform 3
XM_024446377.2 XP_024302145.1 cyclin-dependent kinase 19 isoform X2
XM_047418473.1 XP_047274429.1 cyclin-dependent kinase 19 isoform X8
XM_047418469.1 XP_047274425.1 cyclin-dependent kinase 19 isoform X3

CDK19 Protein Structure

Pkinase

Pkinase: Protein kinase domain (26 - 335)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 502 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 19

  • CDC2-related protein kinase 6

  • CDK8-like cyclin-dependent kinase

  • cell division cycle 2-like 6 (CDK8-like)

  • cell division cycle 2-like protein kinase 6

  • cell division protein kinase 19

  • cyclin-dependent kinase (CDC2-like) 11

  • cyclin-dependent kinase 11

  • death-preventing kinase

Related Diseases

Diseases Alias
Non-Specific Early-Onset Epileptic Encephalopathy

  • Undetermined Early-Onset Epileptic Encephalopathy

  • Non-Specific Eoee

  • Undetermined Eoee
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

  • Star Syndrome

  • Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

  • Syndactyly With Renal And Anogenital Malformations

  • STAR

  • Syndactyly, Telecanthus, Anogenital And Renal Malformations

  • Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Developmental And Epileptic Encephalopathy 87

  • DEE87

  • Epileptic Encephalopathy, Early Infantile, 87

  • Eiee87

  • Developmental And Epileptic Encephalopathy, 87

  • Early Infantile Epileptic Encephalopathy 87
Developmental And Epileptic Encephalopathy

  • Encephalopathy, Developmental And Epileptic
Opitz-Kaveggia Syndrome

  • Fg Syndrome

  • Fgs1

  • Fgs

  • Keller Syndrome

  • OKS

  • Fg Syndrome 1

  • Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum

  • Fg Syndrome Type 1

  • Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum
Ohdo Syndrome

  • Young Simpson Syndrome

  • Ohdo Blepharophimosis Syndrome

  • Blepharophimosis Syndrome Ohdo Type

  • Blepharophimosis Intellectual Disability Syndromes

  • Bmrs

  • Blepharophimosis-Intellectual Disability Syndrome

  • Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth

  • Blepharophimosis Mental Retardation Syndromes

  • Sbbys Syndrome

  • Say Barber Biesecker Young-Simpson Syndrome

  • Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type

  • Bmrs, Ohdo Type

  • Blepharophimosis Syndrome, Ohdo Type

  • Ohdo-Madokoro-Sonoda Syndrome

  • Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type

  • Blepharophimosis - Intellectual Disability Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-101800 Senexin B Inhibitor 99.09% Phase 1
HY-111388B Romaciclib hydrochloride Inhibitor 99.98% Phase 1

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126675A AS2863619 Inhibitor 98.02% Unkown
HY-111388A Romaciclib monohydrochloride Inhibitor 99.29% Unkown
HY-15681 Senexin A Inhibitor 99.58% Unkown
HY-19984 CCT-251921 Inhibitor 99.12% Unkown
HY-122586 BRD6989 Inhibitor 99.54% Unkown
HY-156366 SNX7886 Degrader 99.71% Unkown
HY-126675 AS2863619 free base Inhibitor 99.87% Unkown
HY-139875 JH-XVI-178 Inhibitor 98.87% Unkown
HY-143889 Senexin C Inhibitor 99.19% Unkown
HY-168683 CDK8 ligand 1 Degrader 99.88% Unkown
HY-111388 SEL120-34A Inhibitor 99.49% Unkown
HY-111427 CDK8/19-IN-1 Inhibitor 98.08% Unkown
HY-15681A Senexin A hydrochloride Inhibitor / Unkown
HY-158377 CDK8/19-IN-2 Inhibitor / Unkown
HY-114178 CDK8-IN-2 Inhibitor / Unkown
HY-184544 CDK8 ligand 2 / Unkown
HY-168846 CDK8/19-IN-3 Inhibitor / Unkown
HY-D2311 CDK19 Probe 1 / Unkown
HY-180124 CDK8-IN-20 Inhibitor / Unkown
HY-183074 RO8323 Inhibitor / Unkown
HY-171174 CDK8-IN-16 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CDK19 VGNC VGNC:27122
Mus musculus CDK19 MGD MGI:1925584
Canis familiaris CDK19 VGNC VGNC:39050
Macaca mulatta CDK19 VGNC VGNC:71036
Rattus norvegicus CDK19 RGD RGD:1305435
Felis catus CDK19 VGNC VGNC:102398
Others CDK19 NCBI