JH-XVI-178
Based on 1 publication(s) in Google Scholar
JH-XVI-178 is a highly efficient and selective CDK8/19 inhibitor, with IC50 values of 1 and 2 nM for CDK8 and CDK19, respectively. JH-XVI-178 has a low clearance rate and moderate oral pharmacokinetic properties.
For research use only. We do not sell to patients.
- Purity: 98.87%
- CAS No.: 2648453-53-4
- Formula: C22H22ClN7O
- Molecular Weight:435.91
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) JH-XVI-178
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Biological Activity
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CDK8 1 nM (IC50) |
CDK19 2 nM (IC50) |
JH-XVI-178 (0-1000 nM, 24 h) inhibits the phosphorylation of S727-STAT1 in Jurkat cells[1].
JH-XVI-178 shows off-target inhibition for STK16 and FLT3 (D835V), with an IC50 of 107 nM for STK16[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pharmacokinetic Analysis in Mice Model[1]
| Route | Dose (mg/kg) | AUClast (ng•min/mL) | T1/2 (h) | Cmax (μM) | Clobs (mL•min/kg) | Vss (L/kg) | F (%) |
| Oral | 10 | 51863 | 1.3 | 1.04 | 17 | 0.8 | 8 |