2648453-53-4
2648453-53-4
Chemical Structure
JH-XVI-178
- CAS No.: 2648453-53-4
- Formula:C22H22ClN7O
- Molecular Weight:435.91
IUPAC Name: 8-(3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
InChIKey: YLJSAFSDGFNKAC-UHFFFAOYSA-N
SMILES: ClC1=NNC2=NC=C(C3=CC(C=NN4C)=C4C=C3)C(N5CCC6(CCNC6=O)CC5)=C21
Biological Activity: JH-XVI-178 is a highly efficient and selective CDK8/19 inhibitor, with IC50 values of 1 and 2 nM for CDK8 and CDK19, respectively. JH-XVI-178 has a low clearance rate and moderate oral pharmacokinetic properties[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
JH-XVI-178 | 98.87% | JH-XVI-178 is a highly efficient and selective CDK8/19 inhibitor, with IC50 values of 1 and 2 nM for CDK8 and CDK19, respectively. JH-XVI-178 has a low clearance rate and moderate oral pharmacokinetic properties. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
