TASOR - transcription activation suppressor Gene

Also Known as RAP140; TASOR1; se89-1; C3orf63; FAM208A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23272

About TASOR

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:56,620,132-56,683,265 (from NCBI)

This gene has 11 transcripts (splice variants), 266 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 15.9), lymph node (RPKM 11.5) and 25 other tissues.

Summary

Enables chromatin binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; protein localization to heterochromatin; and regulation of gene expression. Located in heterochromatin and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TASOR Products (7)

mRNA	Protein	Name
NM_001112736.2	NP_001106207.1	protein TASOR isoform a
NM_001363940.1	NP_001350869.1	protein TASOR isoform c
NM_001365635.2	NP_001352564.1	protein TASOR isoform d
NM_001365636.2	NP_001352565.1	protein TASOR isoform e
NM_001365637.2	NP_001352566.1	protein TASOR isoform f
NM_001365638.2	NP_001352567.1	protein TASOR isoform g
NM_015224.3	NP_056039.2	protein TASOR isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	29211708	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26022416	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of gene expression, epigenetic	IDA IDA: Inferred from direct assay	26022416	GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IMP IMP: Inferred from mutant phenotype	29211708	GOA
involved in positive regulation of DNA methylation-dependent heterochromatin formation	IDA IDA: Inferred from direct assay	28581500	GOA
involved in protein localization to heterochromatin	IDA IDA: Inferred from direct assay	28581500	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in heterochromatin	IDA IDA: Inferred from direct assay	28581500	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TASOR Protein Structure

DUF3715

0
300
600
900
1200
1512 a.a.

Protein Preferred Names	Protein Names
protein TASOR	CTCL tumor antigen se89-1

TASOR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TASOR	Q9UK61	MPHOSPH8	Homo sapiens	Q99549	Anti Bait CoIP	26022416

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 75	RP75 Retinitis Pigmentosa, Type 75
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14222	TASOR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14223	TASOR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TASOR	VGNC	VGNC:28783
Felis catus	TASOR	VGNC	VGNC:65962
Mus musculus	TASOR	MGD	MGI:1921694
Canis familiaris	TASOR	VGNC	VGNC:40652
Rattus norvegicus	TASOR	RGD	RGD:1595469
Macaca mulatta	TASOR	VGNC	VGNC:78243
Others	TASOR	NCBI