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TRAM1 - translocation associated membrane protein 1 Gene

Also Known as TRAM; PNAS8; TRAMP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23471

About TRAM1

Cytogenetic location: 8q13.3 Genomic coordinates (GRCh38): 8:70,573,218-70,608,416 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 96.1), urinary bladder (RPKM 71.4) and 25 other tissues.

Summary

This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009]

TRAM1 Products (3)

mRNA	Protein	Name
NM_001317804.2	NP_001304733.1	translocating chain-associated membrane protein 1 isoform 2
NM_001317805.2	NP_001304734.1	translocating chain-associated membrane protein 1 isoform 3
NM_014294.6	NP_055109.1	translocating chain-associated membrane protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18555783	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cotranslational protein targeting to membrane	IDA IDA: Inferred from direct assay	8616892	GOA
involved in protein insertion into ER membrane	IDA IDA: Inferred from direct assay	8616892	GOA
involved in response to unfolded protein	IMP IMP: Inferred from mutant phenotype	20430023	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18555783	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	8616892	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAM1 Protein Structure

TRAM1

TRAM_LAG1_CLN8

0
100
200
300
374 a.a.

Protein Preferred Names	Protein Names
translocating chain-associated membrane protein 1	translocating chain-associating membrane protein

TRAM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRAM1	Q15629	BCAP31	Homo sapiens	P51572	Ub Reconstruction	18555783
Intra	TRAM1	Q15629	BCAP31	Homo sapiens	P51572	Anti Bait CoIP	18555783

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Meckel Syndrome, Type 2	MKS2 Meckel Syndrome 2 Meckel-Gruber Syndrome, Type 2 Meckel Syndrome Type 2
Oropouche Fever	Oropouche Virus Disease Oropouche Mosquito-Borne Viral Fever
Ceroid Lipofuscinosis, Neuronal, 8, Northern Epilepsy Variant	Northern Epilepsy Neuronal Ceroid Lipofuscinosis 8 Northern Epilepsy Variant Epmr Progressive Epilepsy-Intellectual Disability Syndrome, Finnish Type Northern Epilepsy Syndrome Epilepsy, Progressive, With Mental Retardation Northern Epilepsy Variant, Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant Progressive Epilepsy With Mental Retardation, Northern Epilepsy Cln8 Disease, Northern Epilepsy Variant Ncl, Northern Epilepsy Variant Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant CLN8NE Ceroid Lipofuscinosis, Neuronal, 8
Orofaciodigital Syndrome Vi	OFD6 Varadi-Papp Syndrome Varadi Syndrome Joubert Syndrome With Orofaciodigital Defect Orofaciodigital Syndrome Type 6 Orofaciodigital Syndrome 6 Oral-Facial-Digital Syndrome, Type Vi Ofds Vi Polydactyly, Cleft Lip/Palate Or Lingual Lump, And Psychomotor Retardation Polydactyly Cleft Lip Palate Psychomotor Retardation Oral-Facial-Digital Syndrome Type 6 Polydactyly-Cleft Lip/Palate-Psychomotor Retardation Syndrome Polydactyly - Cleft Lip/Palate - Psychomotor Retardation Váradi Syndrome Váradi-Papp Syndrome Joubert Syndrome With Oral-Facial-Digital Syndrome Oral-Facial-Digital Syndrome 6 Joubert-Orofaciodigital Syndrome Orofaciodigital Syndrome, Type Vi

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09091	NCOA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14981	TRAM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20451	Ncoa3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26960	Ncoa3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRAM1	VGNC	VGNC:81678
Canis familiaris	TRAM1	VGNC	VGNC:54123
Macaca mulatta	TRAM1	VGNC	VGNC:84131
Bos taurus	TRAM1	VGNC	VGNC:53882
Mus musculus	TRAM1	MGD	MGI:1919515
Rattus norvegicus	TRAM1	RGD	RGD:1359100
Others	TRAM1	NCBI