QPRT - quinolinate phosphoribosyltransferase Gene

Also Known as QPRTase; HEL-S-90n

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23475

About QPRT

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,679,008-29,698,699 (from NCBI)

This gene has 5 transcripts (splice variants) and 177 orthologues. Broad expression in kidney (RPKM 60.9), liver (RPKM 33.8) and 14 other tissues.

Summary

This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

QPRT Products (3)

mRNA	Protein	Name
NM_001318249.1	NP_001305178.1	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 2
NM_001318250.2	NP_001305179.2	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 3 precursor
NM_014298.6	NP_055113.3	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17868694	GOA
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity	IDA IDA: Inferred from direct assay	3409840	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25464930	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within quinolinate catabolic process	IDA IDA: Inferred from direct assay	9473669	GOA
involved in quinolinate catabolic process	IDA IDA: Inferred from direct assay	3409840	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of catalytic complex	IDA IDA: Inferred from direct assay	17868694	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

QPRT Protein Structure

QRPTase_N

QRPTase_C

0
100
200
297 a.a.

Protein Preferred Names	Protein Names
nicotinate-nucleotide pyrophosphorylase [carboxylating]	epididymis secretory sperm binding protein Li 90n

QPRT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	QPRT	Q15274	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	QPRT	Q15274	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	QPRT	Q15274	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	QPRT	Q15274	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	QPRT	Q15274	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	32296183
Intra	QPRT	Q15274	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	QPRT	Q15274	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	QPRT	Q15274	NLGN3	Homo sapiens	Q9NZ94-2	Confocal	25464930
Intra	QPRT	Q15274	NLGN3	Homo sapiens	Q9NZ94-2	Anti Tag CoIP	25464930
Intra	QPRT	Q15274	EIF4G3	Homo sapiens	O43432	Anti Tag CoIP	28514442
Intra	QPRT	Q15274	QPRT	Homo sapiens	Q15274	Validated Y2H	32296183
Intra	QPRT	Q15274	ADNP	Homo sapiens	Q9H2P0	Anti Tag CoIP	33961781
Intra	QPRT	Q15274	QPRT	Homo sapiens	Q15274	Y2H Prey Pooling	32296183
Intra	QPRT	Q15274	CRY1	Homo sapiens	Q16526	Anti Tag CoIP	28514442
Intra	QPRT	Q15274	ADNP	Homo sapiens	Q9H2P0	Anti Tag CoIP	28514442
Intra	QPRT	Q15274	CRY1	Homo sapiens	Q16526	Anti Tag CoIP	33961781
Intra	QPRT	Q15274	QPRT	Homo sapiens	Q15274	Y2H Array	32296183
Intra	QPRT	Q15274	ACTR6	Homo sapiens	Q9GZN1	Anti Tag CoIP	33961781
Intra	QPRT	Q15274	ACTR6	Homo sapiens	Q9GZN1	Anti Tag CoIP	28514442
Intra	QPRT	Q15274	EIF4G3	Homo sapiens	O43432	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant QPRT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70971	QPRTase Protein, Human (His)	AAH05060.1 (M1-H297)	≥ 95%, as determined by reducing SDS-PAGE.

QPRT Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87047	QPRT Antibody (YA6740)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Pellagra	Niacin Deficiency Niacin-Tryptophan Deficiency Pellagroid Syndrome
Hypertryptophanemia	HYPTRP Hypertryptophanemia, Familial Familial Hypertryptophanemia
Facial Dermatosis	Facial Dermatoses
Familial Adult Myoclonic Epilepsy	Benign Adult Familial Myoclonus Epilepsy Bafme Benign Adult Familial Myoclonic Epilepsy Fame Familial Cortical Myoclonic Tremor And Epilepsy Fcmte Adcme Autosomal Dominant Cortical Myoclonus And Epilepsy Fam Epilepsy, Myoclonic, Familial Adult Epilepsy, Myoclonic, Benign Adult Familial, Type 2
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11503	QPRT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19155	Qprt Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25644	Qprt Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	QPRT	VGNC	VGNC:103699
Felis catus	QPRT	VGNC	VGNC:107812
Macaca mulatta	QPRT	VGNC	VGNC:104747
Rattus norvegicus	QPRT	RGD	RGD:1310309
Mus musculus	QPRT	MGD	MGI:1914625
Others	QPRT	NCBI