QPRT - quinolinate phosphoribosyltransferase Gene

Homo sapiens

Also known as QPRTase; HEL-S-90n

Gene ID: 23475 | Gene type: protein coding

About QPRT

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,679,008-29,698,699 (from NCBI)

This gene has 5 transcripts (splice variants) and 177 orthologues. Broad expression in kidney (RPKM 60.9), liver (RPKM 33.8) and 14 other tissues.

Summary

This gene encodes a key Enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

QPRT Products(3)

mRNA	Protein	Name
NM_001318249.1	NP_001305178.1	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 2
NM_001318250.2	NP_001305179.2	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 3 precursor
NM_014298.6	NP_055113.3	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 1 precursor

QPRT Protein Structure

QRPTase_N

QRPTase_C

0
100
200
297 a.a.

Protein Preferred Names

Protein Names

nicotinate-nucleotide pyrophosphorylase [carboxylating]

epididymis secretory sperm binding protein Li 90n

Recombinant QPRT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70971	QPRTase Protein, Human (His)	AAH05060.1 (M1-H297)	≥95%

Related Diseases

Diseases

Alias

Pellagra

Niacin Deficiency	Niacin-Tryptophan Deficiency
Pellagroid Syndrome

Hypertryptophanemia

HYPTRP	Hypertryptophanemia, Familial
Familial Hypertryptophanemia

Facial Dermatosis

Facial Dermatoses

Familial Adult Myoclonic Epilepsy

Benign Adult Familial Myoclonus Epilepsy	Bafme
Benign Adult Familial Myoclonic Epilepsy	Fame
Familial Cortical Myoclonic Tremor And Epilepsy	Fcmte
Adcme	Autosomal Dominant Cortical Myoclonus And Epilepsy
Fam	Epilepsy, Myoclonic, Familial Adult
Epilepsy, Myoclonic, Benign Adult Familial, Type 2

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11503	QPRT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	QPRT	VGNC	VGNC:103699
Felis catus	QPRT	VGNC	VGNC:107812
Macaca mulatta	QPRT	VGNC	VGNC:104747
Rattus norvegicus	QPRT	RGD	RGD:1310309
Mus musculus	QPRT	MGD	MGI:1914625
Others	QPRT	NCBI