QPRTase Protein, Human (His)
Based on 1 Customer Validation
QPRTase Protein, Human (His) is the recombinant human-derived QPRTase protein, expressed by E. coli, with N-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
QPRTase Protein, Human (His) is the recombinant human-derived QPRTase protein, expressed by E. coli, with N-6*His labeled tag.
Background
QPRT is a key enzyme encoding the catabolism of quinoline, which is an intermediate of the tryptophane-nicotinamide adenine dinucleotide pathway and is one of the most effective endogenous exotoxins against neurons. Elevated levels of quinoline in the brain have been linked to the pathogenesis of neurodegenerative diseases such as epilepsy, Alzheimer's disease and Huntington's disease. QPRT may affect the occurrence and progression of breast cancer through activation of PI3K-AKT signaling pathway, Wnt signaling pathway and cell cycle-related molecules. QPRT may play an important role in the pathogenesis of ASD in Chr16p11.2 deficient carriers. Reducing QPRT expression in gliomas reverses drug resistance in cells. The high expression of QPRT in follicular thyroid cancer can be used as a new screening marker[1][2][3][4].
Verified Bioactivity
The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
AAH05060.1 (M1-H297)
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Molecular Construction
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N-term
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6*His
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QPRTase (M1-H297)
Accession # AAH05060.1 -
C-term
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Protein Length
Full Length
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Synonyms
QPRT; Quinolinate Phosphoribosyltransferase [Decarboxylating]; Quinolinate Phosphoribosyltransferase; Epididymis Secretory Sperm Binding Protein Li 90n; QPRTase; HEL-S-90n; Nicotinate-Nucleotide Pyrophosphorylase (Carboxylating); QAPRTase; Nicotinate-Nucl
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AA Sequence
MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGILAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFALKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH
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Predicted Molecular Mass
33 kDa
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Molecular Weight
Approximately 34 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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