Camk2d - calcium/calmodulin-dependent protein kinase II delta Gene

Rattus norvegicus

Also known as CAMK1; Camk2; Camki; RATCAMKI

Gene ID: 24246 | Gene type: protein coding

About Camk2d

Summary

Enables calmodulin-dependent protein kinase activity; nitric-oxide synthase binding activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; protein phosphorylation; and regulation of calcium ion transmembrane transport. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study epilepsy. Orthologous to human CAMK2D (calcium/Calmodulin dependent protein kinase II delta). [provided by Alliance of Genome Resources, Apr 2022]

Camk2d Products(1)

mRNA	Protein	Name
NM_012519.2	NP_036651.1	calcium/calmodulin-dependent protein kinase type II subunit delta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium/calmodulin-dependent protein kinase activity	IDA IDA: Inferred from direct assay	11925434	RGD
enables nitric-oxide synthase binding	IPI IPI: Inferred from physical interaction	17293490	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12145273	RGD
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	22514276	RGD
enables transmembrane transporter binding	IDA IDA: Inferred from direct assay	18205403	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	12676814	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac muscle cell contraction	IDA IDA: Inferred from direct assay	12676814	RGD
involved in cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	21554860	RGD
involved in endoplasmic reticulum calcium ion homeostasis	IDA IDA: Inferred from direct assay	12676813	RGD
involved in intracellular potassium ion homeostasis	IMP IMP: Inferred from mutant phenotype	11925434	RGD
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	12676814	RGD
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	12676814	RGD
involved in positive regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	17267544	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	18385282	RGD
involved in positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	17267544	RGD
involved in positive regulation of Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	18385282	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	23702479	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	18385282	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17267544	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	11925434	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	23283722	RGD
involved in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IDA IDA: Inferred from direct assay	12676813	RGD
involved in regulation of cardiac muscle cell action potential	IDA IDA: Inferred from direct assay	12676813	RGD
involved in regulation of cell communication by electrical coupling	IDA IDA: Inferred from direct assay	12676813	RGD
involved in regulation of protein localization to plasma membrane	IGI IGI: Inferred from genetic interaction	19188609	RGD
involved in regulation of relaxation of cardiac muscle	IDA IDA: Inferred from direct assay	23283722	RGD
involved in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	12676813	RGD
involved in relaxation of cardiac muscle	IDA IDA: Inferred from direct assay	12676814	RGD
involved in response to hypoxia	IMP IMP: Inferred from mutant phenotype	11925434	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12676814	RGD
located in nucleus	IDA IDA: Inferred from direct assay	12676814	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17293490	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	22360269	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

calcium/calmodulin-dependent protein kinase type II subunit delta

Ca++/calmodulin-dependent protein kinase 2 delta subunit	Ca++/calmodulin-dependent protein kinase II, delta subunit
caM kinase II subunit delta	caM-kinase II delta chain
caMK-II subunit delta	calcium/calmodulin-dependent protein kinase (CaM kinase) I

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124638	MNK inhibitor 9	Inhibitor	99.38%	Unkown
HY-E70797	Biotin-CaMK2δ CAMK2D Recombinant Human Active Protein Kinase		/	Unkown
HY-RS01858	CAMK2D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Camk2d	NCBI	NCBI:817

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