Plcd1 - phospholipase C, delta 1 Gene

Also Known as Plc1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24655

Summary

Enables several functions, including inositol 1,4,5 trisphosphate binding activity; phosphatidylinositol Phospholipase C activity; and phospholipid binding activity. Involved in several processes, including positive regulation of cytosolic calcium ion concentration involved in Phospholipase C-activating G protein-coupled signaling pathway; positive regulation of inositol trisphosphate biosynthetic process; and positive regulation of norepinephrine secretion. Located in several cellular components, including cytosol; membrane raft; and mitochondrial membrane. Used to study congestive heart failure and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (Phospholipase C delta 1). [provided by Alliance of Genome Resources, Apr 2022]

Plcd1 Products (1)

mRNA	Protein	Name
NM_017035.2	NP_058731.2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	9538021	RGD
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	8602259	RGD
enables calcium-dependent phospholipid binding	IMP IMP: Inferred from mutant phenotype	8602259	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	12054611	RGD
enables inositol 1,4,5 trisphosphate binding	IMP IMP: Inferred from mutant phenotype	8602259	RGD
enables phosphatidylinositol phospholipase C activity	IDA IDA: Inferred from direct assay	9287165	RGD
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IDA IDA: Inferred from direct assay	21767260	RGD
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	9804818	RGD
enables phospholipid binding	IDA IDA: Inferred from direct assay	15755258	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18157946	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	8663582	RGD
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	21767260	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16709602	RGD
involved in positive regulation of inositol trisphosphate biosynthetic process	IMP IMP: Inferred from mutant phenotype	16709602	RGD
involved in positive regulation of norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	10473563	RGD
involved in response to aluminum ion	IEP IEP: Inferred from expression pattern	10814511	RGD
involved in response to calcium ion	IMP IMP: Inferred from mutant phenotype	10473563	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	12850505	RGD
involved in response to peptide hormone	IMP IMP: Inferred from mutant phenotype	16709602	RGD
involved in response to prostaglandin F	IEP IEP: Inferred from expression pattern	11517196	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	15107298	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	PLC-III PLC-delta-1 Phospholipase C-delta1 phosphoinositide phospholipase C phosphoinositide phospholipase C-delta-1 phospholipase C delta 1 long form phospholipase C-III

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10656	PLCD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plcd1	NCBI	NCBI:5333