Agxt - alanine--glyoxylate aminotransferase Gene

Also Known as AGT; SPT; Spat

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24792

Summary

This gene encodes alanine-glyoxylate aminotransferase, which catalyzes the interconversion of L-alanine and glyoxylate to pyruvate and glycine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. The longer transcript variant includes an upstream translation start codon and a downstream translation start codon. The upstream start codon initiates the translation of the mitochondrial enzyme precursor while the downstream start codon initiates the translation of the peroxisomal enzyme (see PMID:2332438). [provided by RefSeq, Feb 2013]

Agxt Products (3)

mRNA Protein Name
NM_001270659.1 NP_001257588.1 serine--pyruvate aminotransferase isoform 2
NM_001276706.1 NP_001263635.1 serine--pyruvate aminotransferase, peroxisomal isoform 3
NM_030656.2 NP_085914.2 alanine--glyoxylate aminotransferase isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-serine-pyruvate transaminase activity IDA
IDA: Inferred from direct assay
3894025 RGD
enables alanine-glyoxylate transaminase activity IDA
IDA: Inferred from direct assay
12383475 RGD
enables amino acid binding IDA
IDA: Inferred from direct assay
12383475 RGD
Biological Process GO Annotation Evidence References Source
involved in glycine biosynthetic process, by transamination of glyoxylate IDA
IDA: Inferred from direct assay
12383475 RGD
involved in pyruvate biosynthetic process IDA
IDA: Inferred from direct assay
12383475 RGD
involved in response to cAMP IDA
IDA: Inferred from direct assay
17958 RGD
involved in response to glucocorticoid IDA
IDA: Inferred from direct assay
167860 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
14561759 RGD
located in peroxisome IDA
IDA: Inferred from direct assay
3900009 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alanine--glyoxylate aminotransferase

serine--pyruvate aminotransferase

serine--pyruvate aminotransferase, peroxisomal

  • alanine--glyoxylate and serine--pyruvate aminotransferase

  • angiotensin receptor 2

  • serine--pyruvate aminotransferase, mitochondrial

  • serine-pyruvate aminotransferase

  • serine:pyruvate aminotransferase SPT

  • serine:pyruvate/alanine:glyoxylate aminotransferas

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W023323 (S)-β-Aminoisobutyric acid hydrochloride 99.90% Unkown
HY-159910 LH1513 / Unkown
HY-RS00473 AGXT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00474 AGXT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Agxt NCBI NCBI:189