Slc2a2 - solute carrier family 2 member 2 Gene

Also Known as GTT2; Glut2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25351

About Slc2a2

Primary_assembly 2: 111,611,774-111,639,933 forward strand.mRatBN7.2:CM026975.1

This gene has 3 transcripts (splice variants), 312 orthologues, 12 paralogues and is associated with 15 phenotypes. Biased expression in Liver (RPKM 1233.6) and Kidney (RPKM 253.5).

Summary

Enables D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and Insulin Receptor binding activity. Involved in several processes, including carbohydrate utilization; dehydroascorbic acid transport; and hexose transmembrane transport. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Human ortholog(s) of this gene implicated in Fanconi syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to human SLC2A2 (solute carrier family 2 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc2a2 Products (1)

mRNA Protein Name
NM_012879.2 NP_037011.2 solute carrier family 2, facilitated glucose transporter member 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-glucose transmembrane transporter activity IDA
IDA: Inferred from direct assay
3048704 RGD
enables dehydroascorbic acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
18668520 RGD
enables insulin receptor binding IPI
IPI: Inferred from physical interaction
15665515 RGD
Biological Process GO Annotation Evidence References Source
involved in D-glucose transmembrane transport IDA
IDA: Inferred from direct assay
3048704 RGD
involved in D-glucose transmembrane transport IEP
IEP: Inferred from expression pattern
12095416 RGD
involved in carbohydrate utilization IMP
IMP: Inferred from mutant phenotype
11834736 RGD
involved in cellular response to fatty acid IDA
IDA: Inferred from direct assay
27568038 RGD
involved in cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
27568038 RGD
involved in dehydroascorbic acid transport IDA
IDA: Inferred from direct assay
18668520 RGD
involved in fructose transmembrane transport IEP
IEP: Inferred from expression pattern
12095416 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
12095416 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
12095416 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
11325341 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
1468587 RGD
located in brush border IDA
IDA: Inferred from direct assay
12095416 RGD
located in brush border membrane IDA
IDA: Inferred from direct assay
17272350 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
18668520 RGD
located in endosome IDA
IDA: Inferred from direct assay
15665515 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
3048704 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc2a2 Protein Structure

MFS_GLUT_Class1

MFS_GLUT_Class1: cd17431 (11 - 487)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 522 a.a.
Protein Preferred Names Protein Names

solute carrier family 2, facilitated glucose transporter member 2

  • GLUT-2

  • glucose transporter type 2, liver

  • solute carrier family 2 (facilitated glucose transporter), member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13164 SLC2A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13165 Slc2a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13166 Slc2a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc2a2 NCBI NCBI:6514