2. Gene
  3. METAP1D - methionyl aminopeptidase type 1D, mitochondrial Gene

METAP1D - methionyl aminopeptidase type 1D, mitochondrial Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MAP1D; MAP 1D; Metap1l; MetAP 1D

Gene ID: 254042 | Gene type: protein coding

About METAP1D

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:171,999,953-172,082,430 (from NCBI)

This gene has 7 transcripts (splice variants), 204 orthologues and 7 paralogues. Ubiquitous expression in ovary (RPKM 4.2), endometrium (RPKM 2.3) and 25 other tissues.

Summary

The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC 3.4.11.18) (Serero et al., 2003 [PubMed 14532271]).[supplied by OMIM, Mar 2008]

METAP1D Products(3)

mRNA Protein Name
NM_001322278.2 NP_001309207.1 methionine aminopeptidase 1D, mitochondrial isoform 2
NM_001322279.2 NP_001309208.1 methionine aminopeptidase 1D, mitochondrial isoform 2
NM_199227.3 NP_954697.1 methionine aminopeptidase 1D, mitochondrial isoform 1 precursor

METAP1D Protein Structure

Peptidase_M24

Peptidase_M24: Metallopeptidase family M24 (97 - 321)

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  • 335 a.a.
Protein Preferred Names Protein Names

methionine aminopeptidase 1D, mitochondrial

CDS of metAP-3 within PCR fragment

Recombinant METAP1D Proteins

Cat. No. Product Name Accession Purity
HY-P70862 METAP1D/Methionine aminopeptidase 1D Protein, Human (His) Q6UB28 (R44-A335) ≥95%

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 28

Spinocerebellar Ataxia Type 28

SCA28

Ataxia, Spinocerebellar, Type 28
Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness

Ovarian Dysgenesis With Sensorineural Deafness

Gonadal Dysgenesis, Xx Type

Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance

Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance

Xx Gonodal Dysgenesis-Deafness Syndrome

Xx Gonodal Dysgenesis-Hearing Loss Syndrome

Gonadal Dysgenesis Xx Type Deafness
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08349 METAP1D Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus METAP1D RGD RGD:1307413
Mus musculus METAP1D MGD MGI:1913809
Macaca mulatta METAP1D VGNC VGNC:74632
Bos taurus METAP1D VGNC VGNC:31396
Canis familiaris METAP1D VGNC VGNC:53100
Felis catus METAP1D VGNC VGNC:63455
Others METAP1D NCBI