METAP1D - methionyl aminopeptidase type 1D, mitochondrial Gene

Also Known as MAP1D; MAP 1D; Metap1l; MetAP 1D

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 254042

About METAP1D

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:171,999,953-172,082,430 (from NCBI)

This gene has 7 transcripts (splice variants), 204 orthologues and 7 paralogues. Ubiquitous expression in ovary (RPKM 4.2), endometrium (RPKM 2.3) and 25 other tissues.

Summary

The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, Enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC 3.4.11.18) (Serero et al., 2003 [PubMed 14532271]).[supplied by OMIM, Mar 2008]

METAP1D Products (3)

mRNA Protein Name
NM_001322278.2 NP_001309207.1 methionine aminopeptidase 1D, mitochondrial isoform 2
NM_001322279.2 NP_001309208.1 methionine aminopeptidase 1D, mitochondrial isoform 2
NM_199227.3 NP_954697.1 methionine aminopeptidase 1D, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
33961781 GOA
Cellular Component GO Annotation Evidence Références Source
located in mitochondrion IDA
IDA: Inferred from direct assay
14532271 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METAP1D Protein Structure

Peptidase_M24

Peptidase_M24: Metallopeptidase family M24 (97 - 321)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
Protein Preferred Names Protein Names

methionine aminopeptidase 1D, mitochondrial

  • CDS of metAP-3 within PCR fragment

METAP1D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
METAP1D Q6UB28 PRICKLE4 Homo sapiens Q2TBC4
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant METAP1D Proteins

Cat. No. Nom du produit Accession Pureté
HY-P70862 METAP1D/Methionine aminopeptidase 1D Protein, Human (His) Q6UB28 (R44-A335) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 28

  • Spinocerebellar Ataxia Type 28

  • SCA28

  • Ataxia, Spinocerebellar, Type 28
Perrault Syndrome

  • Gonadal Dysgenesis, Xx Type, With Deafness

  • Ovarian Dysgenesis With Sensorineural Deafness

  • Gonadal Dysgenesis, Xx Type

  • Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance

  • Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance

  • Xx Gonodal Dysgenesis-Deafness Syndrome

  • Xx Gonodal Dysgenesis-Hearing Loss Syndrome

  • Gonadal Dysgenesis Xx Type Deafness
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS08349 METAP1D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19545 Metap1d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26041 Metap1d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus METAP1D RGD RGD:1307413
Mus musculus METAP1D MGD MGI:1913809
Macaca mulatta METAP1D VGNC VGNC:74632
Bos taurus METAP1D VGNC VGNC:31396
Canis familiaris METAP1D VGNC VGNC:53100
Felis catus METAP1D VGNC VGNC:63455
Others METAP1D NCBI