Cryab - crystallin, alpha B Gene

Also Known as AACRYA

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25420

Summary

This gene encodes subunit b, one of two subunits of alpha-crystallin, which is a high molecular weight, soluble aggregate and is a member of the small heat shock protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. It acts as a molecular chaperone and is the major protein in the eye lens, maintaining the transparency and refractive index of the lens. Alternate promoter usage results in different transcript variants encoding the same protein. [provided by RefSeq, Sep 2014]

Cryab Products (1)

mRNA	Protein	Name
NM_012935.4	NP_037067.1	alpha-crystallin B chain

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	15075233	RGD
enables microtubule binding	IDA IDA: Inferred from direct assay	15075233	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19071118	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in microtubule polymerization or depolymerization	IMP IMP: Inferred from mutant phenotype	15075233	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	15358243	RGD
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	18974385	RGD
involved in negative regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	15358243	RGD
involved in protein folding	IDA IDA: Inferred from direct assay	18158587	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	17293487	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	18420382	RGD
involved in stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	18420382	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in I band	IDA IDA: Inferred from direct assay	11945023	RGD
located in M band	IDA IDA: Inferred from direct assay	9396443	RGD
located in actin filament bundle	IDA IDA: Inferred from direct assay	10625651	RGD
located in axon	IDA IDA: Inferred from direct assay	22617993	RGD
located in cardiac myofibril	IDA IDA: Inferred from direct assay	9396443	RGD
located in cell surface	IDA IDA: Inferred from direct assay	17761354	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	22617993	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	22617993	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	22617993	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
alpha-crystallin B chain	Crystallin, alpha polypeptide 2 alpha(B)-crystallin

Cryab Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Cryab	P23928	Crybb1	Mus musculus	Q9WVJ5	Comig Non-Denat Gel	19071118
Cross	Cryab	P23928	Crybb1	Mus musculus	Q9WVJ5	ITC	19071118

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03207	CRYAB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17907	Cryab Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24376	Cryab Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cryab	NCBI	NCBI:1410