CRYAB - crystallin alpha B Gene

Also Known as MFM2; CRYA2; CTPP2; HSPB5; CMD1II; CTRCT16; HEL-S-101

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1410

About CRYAB

Cytogenetic location: 11q23.1 Genomic coordinates (GRCh38): 11:111,908,564-111,923,740 (from NCBI)

This gene has 21 transcripts (splice variants), 218 orthologues, 8 paralogues and is associated with 14 phenotypes. Biased expression in heart (RPKM 784.6), brain (RPKM 268.6) and 5 other tissues.

Summary

Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2019]

CRYAB Products (6)

mRNA	Protein	Name
NM_001289807.1	NP_001276736.1	alpha-crystallin B chain isoform 1
NM_001289808.2	NP_001276737.1	alpha-crystallin B chain isoform 1
NM_001330379.1	NP_001317308.1	alpha-crystallin B chain isoform 2
NM_001368245.1	NP_001355174.1	alpha-crystallin B chain isoform 1
NM_001368246.1	NP_001355175.1	alpha-crystallin B chain isoform 2
NM_001885.3	NP_001876.1	alpha-crystallin B chain isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	23106396	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	12601044	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11700327	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	19646995	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	23106396	GOA
enables structural molecule activity	IDA IDA: Inferred from direct assay	16303126	GOA
enables unfolded protein binding	IPI IPI: Inferred from physical interaction	16303126	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to gamma radiation	IMP IMP: Inferred from mutant phenotype	23542032	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20587334	GOA
involved in negative regulation of amyloid fibril formation	IDA IDA: Inferred from direct assay	23106396	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	14752512	GOA
involved in negative regulation of intracellular transport	IDA IDA: Inferred from direct assay	14752512	GOA
involved in negative regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	23106396	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	12235146	GOA
acts upstream of or within regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	23542032	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14752512	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19464326	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	16303126	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRYAB Protein Structure

Crystallin

HSP20

0
100
175 a.a.

Protein Preferred Names	Protein Names
alpha-crystallin B chain	epididymis secretory protein Li 101

CRYAB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CRYAB	P02511	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	32814053
Intra	CRYAB	P02511	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32814053
Intra	CRYAB	P02511	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Pooling	32814053
Intra	CRYAB	P02511	CRYGS	Homo sapiens	P22914	NMR	24183572
Intra	CRYAB	P02511	CRYGS	Homo sapiens	P22914	DLS	24183572
Intra	CRYAB	P02511	KRTAP6-1	Homo sapiens	Q3LI64	Validated Y2H	32296183
Cross	CRYAB	P02511	Tmem109	Mus musculus	Q3UBX0	Y2H	23542032
Intra	CRYAB	P02511	HSPB1	Homo sapiens	P04792	Anti Tag CoIP	28514442
Intra	CRYAB	P02511	HSPB1	Homo sapiens	P04792	Anti Tag CoIP	33961781
Intra	CRYAB	P02511	HSPB1	Homo sapiens	P04792	Y2H	18330356
Intra	CRYAB	P02511	HSPB1	Homo sapiens	P04792	Anti Bait CoIP	12601044
Intra	CRYAB	P02511	HSPB1	Homo sapiens	P04792	NMR	23188086
Intra	CRYAB	P02511	CTNNB1	Homo sapiens	P35222	Pull Down	22158051
Intra	CRYAB	P02511	CTNNB1	Homo sapiens	P35222	Validated Y2H	32814053
Intra	CRYAB	P02511	CTNNB1	Homo sapiens	P35222	Y2H Array	32814053
Intra	CRYAB	P02511	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	22158051
Intra	CRYAB	P02511	CTNNB1	Homo sapiens	P35222	Y2H Pooling	32814053
Intra	CRYAB	P02511	CRYGC	Homo sapiens	P07315	Experimental Interac	11700327
Intra	CRYAB	P02511	CRYGC	Homo sapiens	P07315	Y2H	12601044
Intra	CRYAB	P02511	CRYGC	Homo sapiens	P07315	Y2H	11700327
Intra	CRYAB	P02511	CRYAA	Homo sapiens	P02489	Y2H	12601044
Intra	CRYAB	P02511	CRYAA	Homo sapiens	P02489	Beta Lactamase	11700327
Intra	CRYAB	P02511	CRYAA	Homo sapiens	P02489	SLCA	22153508
Intra	CRYAB	P02511	CRYAA	Homo sapiens	P02489	Y2H Array	25910212
Intra	CRYAB	P02511	CRYAA	Homo sapiens	P02489	Y2H Prey Pooling	32296183
Intra	CRYAB	P02511	CRYAA	Homo sapiens	P02489	Experimental Interac	11700327
Intra	CRYAB	P02511	CRYAA	Homo sapiens	P02489	Y2H Bait-Prey Pool	25910212
Intra	CRYAB	P02511	CRYAA	Homo sapiens	P02489	Y2H Array	32296183
Intra	CRYAB	P02511	CRYAA	Homo sapiens	P02489	NMR	23188086
Intra	CRYAB	P02511	CRYAA	Homo sapiens	P02489	Validated Y2H	25910212
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	Anti Bait CoIP	12601044
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	3D-EM	22143763
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	TEM	22153508
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	DLS	19651604
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	NMR	22153508
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	Y2H	12601044
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	Crosslink	22143763
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	TEM	21464278
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	SLCA	22153508
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	Solution Sedimentation	19651604
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	TEM	19651604
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	NMR	20802487
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	Y2H	18330356
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	SAXS	21464278
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	NMR	23188086
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	GMS	19651604
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	Crosslink	21464278
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	Solution Sedimentation	22143763
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	TEM	22143763
Intra	CRYAB	P02511	CRYAB	Homo sapiens	P02511	SAXS	20802487
Intra	CRYAB	P02511	HSPB2	Homo sapiens	Q16082	NMR	23188086
Intra	CRYAB	P02511	HSPB2	Homo sapiens	Q16082	Y2H	26465331
Intra	CRYAB	P02511	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	CRYAB	P02511	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	CRYAB	P02511	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	CRYAB	P02511	APP	Homo sapiens	P05067	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CRYAB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7873	Alpha-crystallin B chain/CRYAB Protein, Human (His)	P02511 (M1-K175)	≥ 95%, as determined by reducing SDS-PAGE.

CRYAB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81547	Alpha B Crystallin Antibody (YA1292)	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, IP	Human, Rat, Mouse
HY-P85110	Alpha B Crystallin Antibody (YA4802)	WB, IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Myopathy, Myofibrillar, 2	Alpha-B Crystallinopathy Myofibrillar Myopathy 2 MFM2 Myopathy, Myofibrillar, Alpha-B Crystallin-Related Myopathy, Desmin-Related, Associated With Mutation In The Cryab Gene Myopathy, Myofibrillar, With Or Without Cataract And/Or Cardiomyopathy Alpha-B Crystallin-Related Late-Onset Myopathy Alpha-B Crystallin-Related Late-Onset Distal Myopathy Late-Onset Distal Crystallinopathy Alpha-B Crystallinopathy With Cataract Desmin-Related Myopathy With Cataract Mfm Alpha-B Crystallin-Related Myofibrillar Myopathy Alpha-B Crystallin-Related Myofibrillar Myopathy With Or Without Cataract And/Or Cardiomyopathy Myopathy Cardioskeletal Desmin-Related With Cataract Myopathy Desmin-Related Associated With Mutation In The Cryab Gene Myopathy, Cardioskeletal, Desmin-Related, With Cataract Myopathy, Myofibrillar, Type 2
Cardiomyopathy, Dilated, 1ii	CMD1II Dilated Cardiomyopathy 1ii Cardiomyopathy, Dilated 1ii Cardiomyopathy, Dilated, Type 1ii
Cataract 16, Multiple Types	Cataract 16 Multiple Types CTRCT16 Ctpp2 Cataract, Posterior Polar, 2 Posterior Polar Cataract 2 Cataract, Congenital Lamellar Congenital Lamellar Cataract
Myopathy, Myofibrillar, Fatal Infantile Hypertonic, Alpha-B Crystallin-Related	Mfm, Fatal Infantile Hypertonic, Alpha-B Crystallin-Related MFMFIH-CRYAB Mfm Fatal Infantile Hypertonic Alpha-B Crystallin-Related
Fatal Infantile Hypertonic Myofibrillar Myopathy
Cardiomyopathy, Familial Restrictive, 1	RCM1 Restrictive Cardiomyopathy 1 Rcm Familial Restrictive Cardiomyopathy 1 Cardiomyopathy, Familial Restrictive 1 Cardiomyopathy, Restrictive, Familial, Type 1 Rcm-1
Early-Onset Posterior Polar Cataract
Early-Onset Lamellar Cataract
Early-Onset Nuclear Cataract
Familial Isolated Dilated Cardiomyopathy	Familial Or Idiopathic Dilated Cardiomyopathy
Posterior Polar Cataract	Cataract, Posterior Polar
Alexander Disease	Alexander'S Disease ALXDRD Alexanders Leukodystrophy Axd Demyelinogenic Leukodystrophy Megalencephaly In Infancy Accompanied By Progressive Spasticity And Dementia Alx Dysmyelinogenic Leukodystrophy Fibrinoid Degeneration Of Astrocytes Leukodystrophy With Rosenthal Fibers Alexander Disease Type Ii Axd Type Ii Alexander Disease Type I Axd Type I Alexanders Disease Alexander'S Leukodystrophy
Myopathy	Muscular Diseases Myopathies
Myofibrillar Myopathy	Desmin Related Myopathy Myotilinopathy Myopathy, Myofibrillar Alpha Beta Crystallinopathy Desmin Storage Myopathy Desminopathy Filaminopathy Protein Surplus Myopathy Zaspopathy Myofibrillar Myopathies Myopathy, Myofibrillar, Desmin-Related Myopathy, Desmin Storage Mfm - [Myofibrillar Myopathy]
Myopathy, Myofibrillar, 1	Desmin-Related Myofibrillar Myopathy Desmin-Related Myopathy MFM1 Myopathy, Myofibrillar, Desmin-Related Drm Myofibrillar Myopathy With Arrhythmogenic Right Ventricular Cardiomyopathy Desmin-Related Myopathy With Arrhythmogenic Right Ventricular Cardiomyopathy Myofibrillar Myopathy 1 Desminopathy Muscular Dystrophy, Limb-Girdle, Type 2r Arrhythmogenic Right Ventricular Dysplasia, Familial, 7 Desminopathy, Primary Arrhythmogenic Right Ventricular Dysplasia, Familial, 7, Formerly Arvd7, Formerly Arrhythmogenic Right Ventricular Cardiomyopathy 7, Formerly Arvc7, Formerly Inclusion Body Myopathy 1, Autosomal Dominant, Formerly Ibm1, Formerly Cardiomyopathy, Dilated, 1f And Limb-Girdle Muscular Dystrophy Type 1d, Formerly Cmd1f And Lgmd1d, Formerly Cardiomyopathy, Dilated, With Conduction Defect And Muscular Dystrophy Cdcd3, Formerly Muscular Dystrophy, Limb-Girdle, Type 2r, Formerly Lgmd2r, Formerly Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2r Arrhythmogenic Right Ventricular Cardiomyopathy 7 Arvc7 Arvd7 Autosomal Dominant Inclusion Body Myopathy 1 Cdcd3 Cmd1f And Lgmd1d Desminopathy Primary Dilated Cardiomyopathy 1f And Limb-Girdle Muscular Dystrophy Type 1d Dilated Cardiomyopathy With Conduction Defect And Muscular Dystrophy Familial Arrhythmogenic Right Ventricular Dysplasia 7 Lgmd2r Limb-Girdle Muscular Dystrophy 2r Mfm Desmin-Related Myopathy Myofibrillar Desmin-Related Dystrophy, Muscular, Limb-Girdle, Type 2r
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Presbyopia	Subnormal Accommodation Accommodation Insufficiency Of Old Age
Restrictive Cardiomyopathy	Familial Restrictive Cardiomyopathy Cardiomyopathy, Restrictive Cardiomyopathy, Constrictive Primary Restrictive Cardiomyopathy Rcm Cardiomyopathy Restrictive
Neuronopathy, Distal Hereditary Motor, Type Iic	HMN2C Hmn Iic Dhmn2c Distal Hereditary Motor Neuronopathy Type 2c Distal Hereditary Motor Neuropathy Type Iic Neuronopathy, Distal Hereditary Motor, Type 2c Neuropathy, Distal Hereditary Motor, Type Iic Neuronopathy, Distal Hereditary Motor, 2c Dhmn Iic Neuropathy, Motor, Distal, Hereditary, Type 2c
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Creutzfeldt-Jakob Disease	Variant Creutzfeldt-Jakob Disease CJD Bovine Spongiform Encephalopathy Vcjd Inherited Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Familial Creutzfeldt Jakob Disease Creutzfeldt-Jacob Disease Creutzfeldt Jacob Disease Sporadic Creutzfeldt-Jakob Disease Encephalopathy, Bovine Spongiform Creutzfeldt-Jakob Disease, Variant, Resistance To Creutzfeldt-Jakob Disease, Variant Creutzfeldt Jacob Syndrome Jakob-Creutzfeldt Disease Subacute Spongiform Encephalopathy Transmissible Virus Dementia New Variant Of Cjd Nv-Cjd Variant Cjd Variant Creutzfeldt-Jacob Disease Sporadic Cjd Inherited Cjd Acquired Creutzfeldt-Jakob Disease Variant Mcj Encephalopathy Bovine Spongiform Familial Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Syndrome New Variant Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Sporadic Acquired Cjd Scjd - [Sporadic Creutzfeldt-Jakob Disease] Idiopathic Creutzfeldt-Jakob Disease Creutzfeld-Jakob Disease Nos Vcjd - [Variant Creutzfeldt-Jakob Disease]
Subependymal Giant Cell Astrocytoma	Sega Astrocytoma Subependymal Giant Cell Subependymal Giant-Cell Astrocytoma
Myopathy, Myofibrillar, 4	Myofibrillar Myopathy 4 MFM4 Zaspopathy Myopathy, Myofibrillar, Zasp-Related
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Myopathy, Myofibrillar, 5	Myofibrillar Myopathy 5 MFM5 Myopathy, Myofibrillar, Filamin C-Related Filaminopathy, Autosomal Dominant Filaminopathy Muscle Filaminopathy Autosomal Dominant Filaminopathy Mfm Filamin C-Related Myopathy Myofibrillar Filamin C-Related Myopathy, Myofibrillar, Type 5
Myopathy, Myofibrillar, 6	Myofibrillar Myopathy 6 MFM6 Myopathy, Myofibrillar, Bag3-Related Bag3-Related Myofibrillar Myopathy Muscular Dystrophy, Selcen Type Mfm Bag3-Related Muscular Dystrophy Selcen Type Myopathy Myofibrillar Bag3-Related
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Intraocular Pressure Quantitative Trait Locus	Glaucoma IOPQTL Glaucoma, Susceptibility To Postinfectious Glaucoma Glaucoma With Ocular Inflammation Glaucoma Secondary To Eye Inflammation Traumatic Glaucoma Glaucoma With Concussion Of Globe Glaucoma Due To Ocular Trauma Glaucoma Associated With Ocular Trauma Glaucoma Secondary To Drugs
Distal Hereditary Motor Neuronopathy Type 2	Distal Hereditary Motor Neuropathy, Type Ii Distal Hereditary Motor Neuropathy Type 2 Distal Hereditary Motor Neuropathy Type Ii Hmn Ii Hmn2 Distal Hereditary Motor Neuronopathy, Type Ii Distal Spinal Muscular Atrophy Type 2 Dhmn2 Dsma2 Neuropathy, Motor, Distal, Hereditary, Type Ii Spinal Muscular Atrophy, Jerash Type
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Myopathy, Myofibrillar, 9, With Early Respiratory Failure	Hereditary Myopathy With Early Respiratory Failure Hmerf Myopathy, Proximal, With Early Respiratory Muscle Involvement Edstrom Myopathy Mfm-Titinopathy MFM9 Mprm Hereditary Inclusion Body Myopathy With Early Respiratory Failure Hibm-Erf Myofibrillar Myopathy-Titinopathy Myofibrillar Myopathy With Early Respiratory Failure Myopathy, Distal, With Early Respiratory Failure, Autosomal Dominant Myofibrillar Myopathy 9 Myofibrillar Myopathy 9 With Early Respiratory Failure Autosomal Dominant Distal Myopathy With Early Respiratory Failure Proximal Myopathy With Early Respiratory Muscle Involvement Hereditary Proximal Myopathy With Early Respiratory Failure Admerf Edström Myopathy Hmerf-Erf
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Myotonic Dystrophy 1	Myotonic Dystrophy Dystrophia Myotonica Steinert Disease Myotonic Dystrophy Type 1 Myotonia Atrophica DM1 Congenital Myotonic Dystrophy Myotonia Dystrophica Steinert Myotonic Dystrophy Dystrophia Myotonica 1 Dm Steinert'S Disease Steinert Myotonic Dystrophy Syndrome Myotonic Dystrophy Of Steinert Dystrophia Myotonica Type 1 Myotonic Dystrophy Congenital Dystrophy, Myotonic, Type 1 Dm - [Dystrophia Myotonica] Myotonic Muscular Dystrophy
Pick Disease Of Brain	Pick Disease Pick'S Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Multiple System Atrophy 1	Multiple System Atrophy Shy-Drager Syndrome Msa MSA1 Multiple System Atrophy 1, Susceptibility To Sporadic Olivopontocerebellar Atrophy Multisystem Atrophy Msa1, Susceptibility To Multiple System Atrophy, Susceptibility To Opca Progressive Autonomic Failure With Multiple System Atrophy Sds
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Myopathy, Myofibrillar, 3	Myotilinopathy Myofibrillar Myopathy 3 MFM3 Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1a Lgmd1a Muscular Dystrophy, Limb-Girdle, Type 1a Myopathy, Myofibrillar, Myotilin-Related Muscular Dystrophy, Limb-Girdle, Type 1, Formerly Lgmd1, Formerly Muscular Dystrophy, Limb-Girdle, Type 1a, Formerly Lgmd1a, Formerly Qualitative Or Quantitative Defects Of Myotilin Limb-Girdle Muscular Dystrophy Due To Myotilin Deficiency Distal Myotilinopathy Lgmd1 Limb-Girdle Muscular Dystrophy 1a Mfm Myotilin-Related Muscular Dystrophy, Limb-Girdle, Type 1 Myopathy Myofibrillar Myotylin-Related Myopathy, Myofibrillar, Type 3
Leukodystrophy	Leukodystrophies
Lens Disease	Lens Diseases
Retinal Degeneration	Degeneration Of Retina
Cardiomyopathy, Familial Hypertrophic, 1	Asymmetric Septal Hypertrophy Familial Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy 1 CMH1 Hypertrophic Cardiomyopathy 19 CMH Ventricular Hypertrophy, Hereditary Ash Hypertrophic Subaortic Stenosis, Idiopathic Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Hypertrophic, 1, Digenic Cardiomyopathy, Familial Hypertrophic 1 Hcm Hereditary Ventricular Hypertrophy Idiopathic Hypertrophic Subaortic Stenosis Hypertrophic Cardiomyopathy Cardiomyopathy, Hypertrophic, Familial Cardiomyopathy, Hypertrophic, 1 Familial Asymmetric Septal Hypertrophy Heritable Hypertrophic Cardiomyopathy Fhc Cardiomyopathy, Hypertrophic, Familial, Type 1
Central Nervous System Disease	Cns Disorder CNS Cns Diseases Central Nervous System Diseases
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03207	CRYAB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17907	Cryab Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24376	Cryab Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CRYAB	VGNC	VGNC:39635
Macaca mulatta	CRYAB	VGNC	VGNC:71501
Felis catus	CRYAB	VGNC	VGNC:61197
Bos taurus	CRYAB	VGNC	VGNC:27732
Mus musculus	CRYAB	MGD	MGI:88516
Rattus norvegicus	CRYAB	RGD	RGD:2414
Others	CRYAB	NCBI