CRYGC - crystallin gamma C Gene

Homo sapiens

Also known as CCL; CRYG3; CTRCT2

Gene ID: 1420 | Gene type: protein coding

About CRYGC

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:208,128,137-208,129,828 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 95 orthologues, 14 paralogues and is associated with 6 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among Others. [provided by RefSeq, Jan 2015]

CRYGC Products(1)

mRNA	Protein	Name
NM_020989.4	NP_066269.1	gamma-crystallin C

CRYGC Protein Structure

Crystall

0
100
174 a.a.

Protein Preferred Names

Protein Names

gamma-crystallin C

gamma-crystallin 2-1

Related Diseases

Diseases

Alias

Cataract 2, Multiple Types

CTRCT2	Cataract, Coppock-Like
Cataract 2, Multiple Types, With Or Without Microcornea	Ccl
Cataract 2 Multiple Types	Cataract 2 Multiple Types With Or Without Microcornea
Cataract Coppock-Like	Cataract Embryonic Nuclear
Variable Zonular Pulverulent Cataract	Cataract, Variable Zonular Pulverulent

Cataract 30, Multiple Types

CTRCT30	Cataract 30, Pulverulent
Pulverulent Cataract	Coppock-Like Cataract
Dusty Cataract	Pulverulent Cataract 30
Cataract 30	Cataract, Pulverulent

Cataract Microcornea Syndrome

Microcornea Cataract Syndrome

Cataract-Microcornea Syndrome

Early-Onset Lamellar Cataract

Early-Onset Nuclear Cataract

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Zebrafish Allergy

Danio Rerio Allergy

Pontocerebellar Hypoplasia, Type 14

PCH14	Pontocerebellar Hypoplasia Type 14
Pontocerebellar Hypoplasia 14	Doid:0112325

Shipyard Eye

Epidemic Keratoconjunctivitis

Ekc

Monkeypox

Monkeypox Virus Infections

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

Arthrogryposis, Distal, Type 2b3

DA2B3	Distal Arthrogryposis Type 2b3
Arthrogryposis, Distal, 2b3

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Polyposis Syndrome, Hereditary Mixed, 2

HMPS2	Hereditary Mixed Polyposis Syndrome 2
Polyposis Syndrome, Mixed Hereditary 2	Polyposis Syndrome, Hereditary Mixed, Type 2

Gastric Hemangioma

Hemangioma Of Stomach

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Osebold-Remondini Syndrome

Brachydactyly Type A6	Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities
Bda6	Brachydactyly, Type A6

Bladder Clear Cell Adenocarcinoma

Bladder Mesonephric Adenocarcinoma

Clear Cell Adenocarcinoma Of Bladder

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03214	CRYGC Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CRYGC	VGNC	VGNC:27741
Canis familiaris	CRYGC	VGNC	VGNC:57380
Mus musculus	CRYGC	MGD	MGI:88523
Rattus norvegicus	CRYGC	RGD	RGD:2421

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