Gnai1 - G protein subunit alpha i1 Gene

Also Known as BPGTPB

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25686

Summary

Enables several functions, including GTPase activating protein binding activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including cellular response to forskolin; negative regulation of synaptic transmission; and regulation of cAMP-mediated signaling. Located in several cellular components, including centrosome; membrane raft; and plasma membrane. Part of protein-containing complex. Orthologous to human GNAI1 (G protein subunit alpha i1). [provided by Alliance of Genome Resources, Apr 2022]

Gnai1 Products (1)

mRNA	Protein	Name
NM_013145.2	NP_037277.1	guanine nucleotide-binding protein G(i) subunit alpha-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor binding	IDA IDA: Inferred from direct assay	25037222	RGD
enables G protein-coupled serotonin receptor binding	IPI IPI: Inferred from physical interaction	16772521	RGD
enables GDP binding	IDA IDA: Inferred from direct assay	8073283	RGD
enables GDP binding	IMP IMP: Inferred from mutant phenotype	8939752	RGD
enables GTP binding	IDA IDA: Inferred from direct assay	19703466	RGD
enables GTP binding	IMP IMP: Inferred from mutant phenotype	8073283	RGD
enables GTPase activating protein binding	IDA IDA: Inferred from direct assay	9108480	RGD
enables GTPase activity	IDA IDA: Inferred from direct assay	21158412	RGD
enables GTPase activity	IMP IMP: Inferred from mutant phenotype	8939752	RGD
enables magnesium ion binding	IDA IDA: Inferred from direct assay	19703466	RGD
enables magnesium ion binding	IMP IMP: Inferred from mutant phenotype	8073283	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11387333	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	25037222	RGD
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11923410	RGD
involved in cellular response to forskolin	IMP IMP: Inferred from mutant phenotype	19703466	RGD
involved in negative regulation of synaptic transmission	IMP IMP: Inferred from mutant phenotype	11923410	RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	16299499	RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IEP IEP: Inferred from expression pattern	16299499	RGD
involved in regulation of cAMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	19703466	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	17635935	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	17635935	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16299499	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	16870394	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	16299499	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	9108480	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
guanine nucleotide-binding protein G(i) subunit alpha-1	adenylate cyclase-inhibiting G alpha protein guanine nucleotide binding protein (G protein), alpha inhibiting 1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 guanine nucleotide binding protein, alpha inhibiting

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05534	GNAI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22533	Gnai1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29053	Gnai1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gnai1	NCBI	NCBI:2770