MOB4 - MOB family member 4, phocein Gene

Also Known as 2C4D; MOB1; MOB3; PHOCN; PREI3; CGI-95; MOBKL3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25843

About MOB4

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:197,515,554-197,553,699 (from NCBI)

This gene has 8 transcripts (splice variants), 234 orthologues and 6 paralogues. Ubiquitous expression in adrenal (RPKM 20.9), esophagus (RPKM 14.5) and 25 other tissues.

Summary

This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]

MOB4 Products (4)

mRNA Protein Name
NM_001100819.3 NP_001094289.1 MOB-like protein phocein isoform 3
NM_001204094.1 NP_001191023.1 MOB-like protein phocein isoform 2
NM_015387.5 NP_056202.2 MOB-like protein phocein isoform 1
NM_199482.4 NP_955776.1 MOB-like protein phocein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18782753 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
33633399 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of hippo signaling IDA
IDA: Inferred from direct assay
33633399 GOA
Cellular Component GO Annotation Evidence References Source
part of FAR/SIN/STRIPAK complex IDA
IDA: Inferred from direct assay
18782753 GOA
located in Golgi apparatus IDA
IDA: Inferred from direct assay
11251078 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOB4 Protein Structure

Mob1_phocein

Mob1_phocein: Mob1/phocein family (40 - 208)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

MOB-like protein phocein

  • MOB1, Mps One Binder kinase activator-like 3

MOB4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MOB4 Q9Y3A3 STRN Homo sapiens O43815
Anti Tag CoIP
18782753
Intra
MOB4 Q9Y3A3 STRN Homo sapiens O43815
TAP
18782753
Intra
MOB4 Q9Y3A3 STRN3 Homo sapiens Q13033-2
Anti Tag CoIP
19156129
Intra
MOB4 Q9Y3A3 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
18782753
Intra
MOB4 Q9Y3A3 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
19156129
Intra
MOB4 Q9Y3A3 CTTNBP2NL Homo sapiens Q9P2B4
TAP
18782753
Intra
MOB4 Q9Y3A3 TRAF3IP3 Homo sapiens Q9Y228
Anti Tag CoIP
18782753
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MOB4 Proteins

Cat. No. Product Name Accession Purity
HY-P70940 MOB4 Protein, Human (His) Q9Y3A3 (M1-A225) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cerebral Cavernous Malformations 3

  • Cerebral Cavernous Malformation 3

  • CCM3

  • Cerebral Cavernous Malformations-3

  • Cavernous Angiomatous Malformations

  • Cavernous Hemangioma Of The Brain

  • Cerebral Capillary Malformations

  • Cerebral Cavernoma

  • Familial Cavernous Angioma

  • Cerebral Cavernous Malformations, Type 3
Osteogenesis Imperfecta, Type X

  • Osteogenesis Imperfecta Type 10

  • OI10

  • Osteogenesis Imperfecta Type X

  • Oi, Type X

  • Osteogenesis Imperfecta 10

  • Oi Type X

  • Oi-X
Cerebral Cavernous Malformations

  • Cerebral Cavernous Malformation

  • Cavernous Malformations Of Cns And Retina

  • Cerebral Cavernous Malformation 1

  • Cavernous Angiomatous Malformations

  • Cerebral Capillary Malformations

  • CCM

  • Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

  • Familial Cavernous Angioma

  • Cavernous Angioma

  • Familial Cerebral Cavernous Malformation

  • Cerebral Cavernous Malformations 1

  • Cavernous Angioma, Familial

  • Cam

  • Cerebral Cavernous Malformations-1

  • Cavernoma

  • Central Nervous System Cavernous Hemangioma

  • Cerebral Cavernous Hemangioma

  • Familial Cavernous Hemangioma

  • Familial Cavernous Malformation

  • Familial Cerebral Cavernous Angioma

  • Intracerebral Cavernous Hemangioma

  • CCM1

  • Cavernous Hemangioma Of The Brain

  • Cerebral Cavernoma

  • Cerebral Cavernous Malformations, Type 1

  • Hemangioma, Cavernous, Central Nervous System

  • Hemangioma, Cavernous

  • Angioma, Cavernous
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08577 MOB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180517 PP48 / Unkown
HY-RS20297 Mob4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26805 Mob4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MOB4 RGD RGD:620183
Mus musculus MOB4 MGD MGI:104899