MRGPRX1 - MAS related GPR family member X1 Gene

Also Known as GPCR; MGRG2; MRGX1; SNSR4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 259249

About MRGPRX1

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,933,499-18,939,414 (from NCBI)

This gene has 2 transcripts (splice variants), 440 orthologues and 10 paralogues.

Summary

Enables transmembrane signaling receptor activity. Involved in cell surface receptor signaling pathway and response to chloroquine. Predicted to be located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]

MRGPRX1 Products (2)

mRNA Protein Name
NM_001393578.1 NP_001380507.1 mas-related G-protein coupled receptor member X1
NM_147199.4 NP_671732.3 mas-related G-protein coupled receptor member X1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables transmembrane signaling receptor activity IMP
IMP: Inferred from mutant phenotype
20004959 GOA
Biological Process GO Annotation Evidence References Source
involved in cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20004959 GOA
involved in response to chloroquine IMP
IMP: Inferred from mutant phenotype
20004959 GOA
involved in signal transduction IMP
IMP: Inferred from mutant phenotype
26582731 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRGPRX1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (44 - 272)

  • 0
  • 100
  • 200
  • 300
  • 322 a.a.
Protein Preferred Names Protein Names

mas-related G-protein coupled receptor member X1

  • G protein-coupled receptor MRGX1

Related Diseases

Diseases Alias
Neurodermatitis
Nephrogenic Diabetes Insipidus

  • Vasopressin-Resistant Diabetes Insipidus

  • Diabetes Insipidus, Nephrogenic

  • Diabetes Insipidus Nephrogenic

  • Congenital Nephrogenic Diabetes Insipidus

  • Adh Resistant Diabetes Insipidus

  • Diabetes Insipidus Nephrogenic X-Linked

  • Diabetes Insipidus Nephrogenic Type 1

  • Adh-Resistant Diabetes Insipidus

  • Diabetes Insipidus Renalis

  • Ndi

  • Renal Diabetes Insipidus

  • Familial Nephrogenic Diabetes

  • Antidiuretic-Hormone-Resistant Diabetes Insipidus

  • Adiuretin-Resistant Diabetes Insipidus

  • Ndi - [Nephrogenic Diabetes Insipidus]

  • Diabetes Tenuifluus

  • Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus

  • Hereditary Nephrogenic Diabetes Insipidus

  • Familial Nephrogenic Diabetes Insipidus

  • Primary Nephrogenic Diabetes Insipidus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-130118 MRGPRX1 agonist 1 Agonist 99.95% Unkown
HY-110285 ML382 99.89% Unkown
HY-173003 EP-3945 Agonist 99.17% Unkown
HY-143878 MRGPRX1 agonist 2 Agonist / Unkown
HY-143879 MRGPRX1 agonist 3 Agonist / Unkown
HY-143880 MRGPRX1 agonist 4 Agonist / Unkown
HY-180802 BCFTP Modulator 99.46% Unkown
HY-RS08650 MRGPRX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17519 Mrgprx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W242735 4-Aminobenzimidamide Hydrochloride Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MRGPRX1 RGD RGD:1591915
Others MRGPRX1 NCBI