MRGPRX1 - MAS related GPR family member X1 Gene

Homo sapiens

Also known as GPCR; MGRG2; MRGX1; SNSR4

Gene ID: 259249 | Gene type: protein coding

About MRGPRX1

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,933,499-18,939,414 (from NCBI)

This gene has 2 transcripts (splice variants), 440 orthologues and 10 paralogues.

Summary

Enables transmembrane signaling receptor activity. Involved in cell surface receptor signaling pathway and response to chloroquine. Predicted to be located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]

MRGPRX1 Products(2)

mRNA	Protein	Name
NM_001393578.1	NP_001380507.1	mas-related G-protein coupled receptor member X1
NM_147199.4	NP_671732.3	mas-related G-protein coupled receptor member X1

MRGPRX1 Protein Structure

7tm_1

0
100
200
300
322 a.a.

Protein Preferred Names

Protein Names

mas-related G-protein coupled receptor member X1

G protein-coupled receptor MRGX1

Related Diseases

Diseases

Alias

Neurodermatitis

Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus	Diabetes Insipidus, Nephrogenic
Diabetes Insipidus Nephrogenic	Congenital Nephrogenic Diabetes Insipidus
Adh Resistant Diabetes Insipidus	Diabetes Insipidus Nephrogenic X-Linked
Diabetes Insipidus Nephrogenic Type 1	Adh-Resistant Diabetes Insipidus
Diabetes Insipidus Renalis	Ndi
Renal Diabetes Insipidus	Familial Nephrogenic Diabetes
Antidiuretic-Hormone-Resistant Diabetes Insipidus	Adiuretin-Resistant Diabetes Insipidus
Ndi - [Nephrogenic Diabetes Insipidus]	Diabetes Tenuifluus
Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus	Hereditary Nephrogenic Diabetes Insipidus
Familial Nephrogenic Diabetes Insipidus	Primary Nephrogenic Diabetes Insipidus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130118	MRGPRX1 agonist 1		99.97%	Unkown
HY-110285	ML382		99.89%	Unkown
HY-143878	MRGPRX1 agonist 2	Agonist	/	Unkown
HY-143879	MRGPRX1 agonist 3	Agonist	/	Unkown
HY-143880	MRGPRX1 agonist 4	Agonist	/	Unkown
HY-RS08650	MRGPRX1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MRGPRX1	RGD	RGD:1591915

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