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FBXL5 - F-box and leucine rich repeat protein 5 Gene

Also Known as FBL4; FBL5; FLR1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26234

About FBXL5

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:15,604,381-15,681,569 (from NCBI)

This gene has 13 transcripts (splice variants), 238 orthologues and 15 paralogues. Ubiquitous expression in kidney (RPKM 49.5), fat (RPKM 39.0) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]

FBXL5 Products (3)

mRNA	Protein	Name
NM_001193534.2	NP_001180463.1	F-box/LRR-repeat protein 5 isoform 3
NM_001193535.2	NP_001180464.1	F-box/LRR-repeat protein 5 isoform 4
NM_012161.4	NP_036293.1	F-box/LRR-repeat protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables iron ion binding	IDA IDA: Inferred from direct assay	19762596	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17532294	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	17532294	GOA
involved in intracellular iron ion homeostasis	IEP IEP: Inferred from expression pattern	19762597	GOA
involved in intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	19762596	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	17532294	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	19762596	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17532294	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXL5 Protein Structure

Hemerythrin

F-box-like

LRR_6

0
200
400
600
691 a.a.

Protein Preferred Names	Protein Names
F-box/LRR-repeat protein 5	F-box protein FBL4/FBL5

FBXL5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FBXL5	Q9UKA1	HERC2	Homo sapiens	O95714	Anti Tag CoIP	33961781
Intra	FBXL5	Q9UKA1	HERC2	Homo sapiens	O95714	Anti Tag CoIP	28514442
Intra	FBXL5	Q9UKA1	IREB2	Homo sapiens	P48200	Anti Tag CoIP	19762597
Intra	FBXL5	Q9UKA1	SKP1	Homo sapiens	P63208	Y2H Prey Pooling	25416956
Intra	FBXL5	Q9UKA1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	33961781
Intra	FBXL5	Q9UKA1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	28514442
Intra	FBXL5	Q9UKA1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	19762597
Intra	FBXL5	Q9UKA1	SKP1	Homo sapiens	P63208	Y2H	21516116

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spastic Paraplegia 38, Autosomal Dominant	SPG38 Hereditary Spastic Paraplegia 38 Autosomal Dominant Spastic Paraplegia Type 38 Autosomal Dominant Spastic Paraplegia 38
Alzheimer Disease 3	AD3 Alzheimer Disease, Type 3 Alzheimer Disease, Type 3, With Spastic Paraparesis And Apraxia Alzheimer Disease, Type 3, With Spastic Paraparesis And Unusual Plaques Alzheimer'S Disease 3 Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Apraxia Alzheimer Disease 3, Early-Onset Alzheimer Disease, Familial, 3 Alzheimer Disease, Protection Against, Due To Apoe3-Christchurch Alzheimer Disease 3, Early Onset Alzheimer Disease Familial 3 Early-Onset Familial Alzheimer Disease 3 Familial Alzheimer Disease 3 Familial Alzheimer Disease 3 With Spastic Paraparesis And Apraxia Familial Alzheimer Disease 3 With Spastic Paraparesis And Unusual Plaques Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Unusual Plaques Alzheimer Disease, Familial, Type 3
Deficiency Anemia	Anemia Deficiency Anemias Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04793	FBXL5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20017	Fbxl5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26520	Fbxl5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FBXL5	VGNC	VGNC:81408
Felis catus	FBXL5	VGNC	VGNC:78493
Rattus norvegicus	FBXL5	RGD	RGD:1306887
Mus musculus	FBXL5	MGD	MGI:2152883
Canis familiaris	FBXL5	VGNC	VGNC:40761
Bos taurus	FBXL5	VGNC	VGNC:28891
Others	FBXL5	NCBI