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ANKRD2 - ankyrin repeat domain 2 Gene

Also Known as ARPP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26287

About ANKRD2

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:97,572,441-97,583,884 (from NCBI)

This gene has 4 transcripts (splice variants), 173 orthologues and 1 paralogue. Biased expression in heart (RPKM 16.8), kidney (RPKM 3.2) and 1 other tissue.

Summary

This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

ANKRD2 Products (5)

mRNA	Protein	Name
NM_001129981.3	NP_001123453.1	ankyrin repeat domain-containing protein 2 isoform b
NM_001291218.2	NP_001278147.1	ankyrin repeat domain-containing protein 2 isoform c
NM_001291219.3	NP_001278148.2	ankyrin repeat domain-containing protein 2 isoform f
NM_001346793.2	NP_001333722.1	ankyrin repeat domain-containing protein 2 isoform e
NM_020349.4	NP_065082.2	ankyrin repeat domain-containing protein 2 isoform a

ANKRD2 Protein Structure

Ank_2

0
100
200
300
360 a.a.

Protein Preferred Names	Protein Names
ankyrin repeat domain-containing protein 2	ankyrin repeat domain 2 (stretch responsive muscle)

ANKRD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ANKRD2	Q9GZV1	MAPK6	Homo sapiens	Q16659	Y2H Array	32296183
Intra	ANKRD2	Q9GZV1	MAPK6	Homo sapiens	Q16659	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neuronopathy, Distal Hereditary Motor, Type Viii	Autosomal Dominant Congenital Benign Spinal Muscular Atrophy HMN8 Dhmn8 Neuropathy, Distal Hereditary Motor, Type Viii Distal Hereditary Motor Neuronopathy Type 8 Autosomal Dominant Benign Distal Spinal Muscular Atrophy Congenital Benign Spinal Muscular Atrophy With Contractures Congenital Nonprogressive Spinal Muscular Atrophy Spinal Muscular Atrophy, Distal, Congenital Nonprogressive Spinal Muscular Atrophy, Congenital Benign, With Contractures Distal Hereditary Motor Neuropathy Type Viii Neuronopathy, Distal Hereditary Motor, 8 Distal Spinal Muscular Atrophy, Congenital Non-Progressive Spinal Muscular Atrophy Congenital Benign With Contractures
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2g	Lgmd2g Limb-Girdle Muscular Dystrophy Due To Telethonin Deficiency Muscular Dystrophy, Limb-Girdle, Type 2g
Tibial Muscular Dystrophy	Tmd Udd Myopathy Distal Titinopathy Finnish Tibial Muscular Dystrophy Tardive Tibial Muscular Dystrophy Udd Type Distal Myopathy Udd Distal Myopathy Udd-Markesbery Muscular Dystrophy Distal Myopathy, Udd Type Distal Myopathies Tibial Muscular Dystrophy, Tardive
Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant	EDMD2 Autosomal Dominant Emery-Dreifuss Muscular Dystrophy Emd2 Emery-Dreifuss Muscular Dystrophy, Autosomal Dominant Scapuloilioperoneal Atrophy With Cardiopathy Muscular Dystrophy With Early Contractures And Cardiomyopathy, Autosomal Dominant Hauptmann-Thannhauser Muscular Dystrophy Cardiomyopathy, Dilated, With Quadriceps Myopathy Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 2 Muscular Dystrophy, Limb-Girdle, Type 1b Muscular Dystrophy, Limb-Girdle, Type 1b, Formerly Lgmd1b, Formerly Muscular Dystrophy, Proximal, Type 1b, Formerly Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1b Lgmd1b Limb-Girdle Muscular Dystrophy 1b Muscular Dystrophy, Proximal, Type 1b Muscular Dystrophy With Early Contractures And Cardiomyopathy Autosomal Dominant
Myopathy, Myofibrillar, 4	Myofibrillar Myopathy 4 MFM4 Zaspopathy Myopathy, Myofibrillar, Zasp-Related
Acute Basophilic Leukemia
Myopathy, Spheroid Body	Spheroid Body Myopathy Autosomal Dominant Spheroid Body Myopathy SBM
Urofacial Syndrome 1	Urofacial Syndrome Ochoa Syndrome Hydronephrosis With Peculiar Facial Expression Ufs Inverted Smile And Occult Neuropathic Bladder Partial Facial Palsy With Urinary Abnormalities UFS1 Urofacial Ochoa'S Syndrome Urofacial Syndrome Type 1 Facial Palsy, Partial, With Urinary Abnormalities Hydronephrosis-Inverted Smile Inverted Smile-Neurogenic Bladder Hydronephrosis-Inverted Smile Syndrome Inverted Smile-Neurogenic Bladder Syndrome Partial Facial Palsy Partial With Urinary Abnormalities Urologic Diseases
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Autosomal Recessive Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00717	ANKRD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ANKRD2	VGNC	VGNC:69815
Rattus norvegicus	ANKRD2	RGD	RGD:1305104
Bos taurus	ANKRD2	VGNC	VGNC:25915
Mus musculus	ANKRD2	MGD	MGI:1861447
Felis catus	ANKRD2	VGNC	VGNC:97351
Canis familiaris	ANKRD2	VGNC	VGNC:37889