Erc1 - ELKS/RAB6-interacting/CAST family member 1 Gene

Rattus norvegicus

Also known as ERC; CAST; Elks; Cast2; ERC1b; Rab6ip2

Gene ID: 266806 | Gene type: protein coding

About Erc1

Summary

Enables PDZ domain binding activity. Predicted to be involved in several processes, including I-kappaB phosphorylation; chemical synaptic transmission; and maintenance of presynaptic active zone structure. Located in membrane; postsynaptic density; and synaptic vesicle. Is active in presynaptic active zone cytoplasmic component. Orthologous to human ERC1 (ELKS/RAB6-interacting/CAST family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Erc1 Products(3)

mRNA	Protein	Name
NM_001394882.1	NP_001381811.1	ELKS/Rab6-interacting/CAST family member 1 isoform 1
NM_001394883.1	NP_001381812.1	ELKS/Rab6-interacting/CAST family member 1 isoform 2
NM_001394884.1	NP_001381813.1	ELKS/Rab6-interacting/CAST family member 1 isoform 3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IDA IDA: Inferred from direct assay	12391317	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12391317	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	27626661	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	27626661	RGD
is active in presynaptic active zone cytoplasmic component	IDA IDA: Inferred from direct assay	12391317	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	27626661	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ELKS/Rab6-interacting/CAST family member 1

CAZ-associated structural protein 2	ERC protein 1
ERC-1	RIM-Binding Protein
Rab6-interacting protein 2

Erc1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Erc1	Q811U3	Rims1	Rattus norvegicus	Q9JIR4	Y2H Array	12391317
Intra	Erc1	Q811U3	Rims1	Rattus norvegicus	Q9JIR4	Y2H	12391317
Intra	Erc1	Q811U3	Rims1	Rattus norvegicus	Q9JIR4	Pull Down	12391317
Intra	Erc1	Q811U3	Rims1	Rattus norvegicus	Q9JIR4	Imaging	12391317
Intra	Erc1	Q811U3	Rims1	Rattus norvegicus	Q9JIR4	NMR	21241895

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04476	ERC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Erc1	NCBI	NCBI:23085

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