Erc1 - ELKS/RAB6-interacting/CAST family member 1 Gene

Also Known as ERC; CAST; Elks; Cast2; ERC1b; Rab6ip2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 266806

Summary

Enables PDZ domain binding activity. Predicted to be involved in several processes, including I-kappaB phosphorylation; chemical synaptic transmission; and maintenance of presynaptic active zone structure. Located in membrane; postsynaptic density; and synaptic vesicle. Is active in presynaptic active zone cytoplasmic component. Orthologous to human ERC1 (ELKS/RAB6-interacting/CAST family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Erc1 Products (3)

mRNA Protein Name
NM_001394882.1 NP_001381811.1 ELKS/Rab6-interacting/CAST family member 1 isoform 1
NM_001394883.1 NP_001381812.1 ELKS/Rab6-interacting/CAST family member 1 isoform 2
NM_001394884.1 NP_001381813.1 ELKS/Rab6-interacting/CAST family member 1 isoform 3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IDA
IDA: Inferred from direct assay
12391317 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12391317 RGD
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
27626661 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
27626661 RGD
is active in presynaptic active zone cytoplasmic component IDA
IDA: Inferred from direct assay
12391317 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
27626661 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ELKS/Rab6-interacting/CAST family member 1

  • CAZ-associated structural protein 2

  • ERC protein 1

  • ERC-1

  • RIM-Binding Protein

  • Rab6-interacting protein 2

Erc1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Erc1 Q811U3 Rims1 Rattus norvegicus Q9JIR4
Y2H Array
12391317
Intra
Erc1 Q811U3 Rims1 Rattus norvegicus Q9JIR4
Y2H
12391317
Intra
Erc1 Q811U3 Rims1 Rattus norvegicus Q9JIR4
Pull Down
12391317
Intra
Erc1 Q811U3 Rims1 Rattus norvegicus Q9JIR4
Imaging
12391317
Intra
Erc1 Q811U3 Rims1 Rattus norvegicus Q9JIR4
NMR
21241895
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04476 ERC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Erc1 NCBI NCBI:23085