OPLAH - 5-oxoprolinase, ATP-hydrolysing Gene

Also Known as OPLA; OPLAHD; 5-Opase

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26873

About OPLAH

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,050,322-144,063,961 (from NCBI)

This gene has 4 transcripts (splice variants), 178 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 16.8), kidney (RPKM 6.8) and 20 other tissues.

Summary

The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012]

OPLAH Products (1)

mRNA	Protein	Name
NM_017570.5	NP_060040.1	5-oxoprolinase

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OPLAH Protein Structure

Hydant_A_N

Hydantoinase_A

Hydantoinase_B

0
200
400
600
800
1000
1200
1288 a.a.

Protein Preferred Names	Protein Names
5-oxoprolinase	5-oxo-L-prolinase

OPLAH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OPLAH	O14841	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	OPLAH	O14841	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	OPLAH	O14841	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	OPLAH	O14841	ccsb orf id: 1345	Homo sapiens	EBI-22333177	Y2H Prey Pooling	32296183
Intra	OPLAH	O14841	TPK1	Homo sapiens	Q9H3S4	Validated Y2H	32296183
Intra	OPLAH	O14841	OPLAH	Homo sapiens	O14841	Y2H Array	32296183
Intra	OPLAH	O14841	TPK1	Homo sapiens	Q9H3S4	Y2H Array	32296183
Intra	OPLAH	O14841	HOXA1	Homo sapiens	P49639	Y2H Pooling	21653829
Intra	OPLAH	O14841	ccsb orf id: 1345	Homo sapiens	EBI-22333177	Y2H Array	32296183
Intra	OPLAH	O14841	OPLAH	Homo sapiens	O14841	Validated Y2H	32296183
Intra	OPLAH	O14841	OPLAH	Homo sapiens	O14841	Y2H Prey Pooling	32296183
Intra	OPLAH	O14841	TPK1	Homo sapiens	Q9H3S4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

OPLAH Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810113	OPLAH Antibody (YA9457)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
5-Oxoprolinase Deficiency	OPLAHD Oxoprolinuria Due To 5-Oxoprolinase Deficiency Oxoprolinuria Due To Oxoprolinase Deficiency 5-Alpha-Oxoprolinase Deficiency
Glutathione Synthetase Deficiency	5-Oxoprolinuria Pyroglutamic Aciduria Pyroglutamicaciduria Glutathione Synthetase Deficiency With 5-Oxoprolinuria GSSD Oxoprolinase Deficiency 5-Oxoprolinemia Deficiency Of Glutathione Synthase Deficiency Of Glutathione Synthetase Pyroglutamic Acidemia GSS DEFICIENCY Gluthathione Synthetase Deficiency 5-Oxoprolinase Deficiency
Tinea Favosa	Favus
Mend Syndrome	Male Ebp Disorder With Neurological Defects MEND Male Ebp Disorder With Neurologic Defects
Hawkinsinuria	4-Alpha-Hydroxyphenylpyruvate Hydroxylase Deficiency 4-Hppd Deficiency 4-Hydroxyphenylpyruvic Acid Dioxygenase Deficiency HWKS HAWK
Metabolic Acidosis
Hypoinsulinemic Hypoglycemia With Hemihypertrophy	Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy HIHGHH
Cystinosis	Cystine Storage Disease Cystine Diathesis Cystine Disease Cystinoses Protein Defect Of Cystin Transport Cystin Transport, Protein Defect Of Nephropathic Cystinosis Protein Defect Of Cystine Transport
Ck Syndrome	CKS X-Linked Intellectual Disability-Microcephaly-Cortical Malformation-Thin Habitus Syndrome Mental Retardation, X-Linked, With Thin Body Habitus And Cortical Malformation
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Hypotonia-Cystinuria Syndrome	Cystinuria With Mitochondrial Disease 2p21 Microdeletion Syndrome HCS Homozygous 2p16 Deletion Syndrome, Formerly 2p21 Deletion Syndrome Del(2)(P21) Monosomy 2p21 Atypical Hypotonia-Cystinuria Syndrome Atypical Hcs
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09794	OPLAH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OPLAH	MGD	MGI:1922725
Bos taurus	OPLAH	VGNC	VGNC:53869
Felis catus	OPLAH	VGNC	VGNC:68630
Canis familiaris	OPLAH	VGNC	VGNC:49607
Rattus norvegicus	OPLAH	RGD	RGD:620956
Macaca mulatta	OPLAH	VGNC	VGNC:84096
Others	OPLAH	NCBI