Nup98 - nucleoporin 98 Gene

Also Known as Nup96; 4732457F17

Species: Mus musculus

Gene Type: protein coding
Gene ID: 269966

Summary

Predicted to enable several functions, including nuclear localization sequence binding activity; promoter-specific chromatin binding activity; and transcription coactivator activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nuclear pore complex assembly; positive regulation of mRNA splicing, via spliceosome; and protein import into nucleus. Predicted to act upstream of or within mRNA transport; protein transport; and proteolysis. Located in nucleus. Is expressed in several structures, including nervous system and neural retina. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human NUP98 (nucleoporin 98 and 96 precursor). [provided by Alliance of Genome Resources, Apr 2022]

Nup98 Products (13)

mRNA Protein Name
NM_001287164.2 NP_001274093.1 nuclear pore complex protein Nup98-Nup96 isoform 1 precursor
NM_001287165.2 NP_001274094.1 nuclear pore complex protein Nup98-Nup96 isoform 3
NM_001287166.2 NP_001274095.1 nuclear pore complex protein Nup98-Nup96 isoform 4
NM_001287167.2 NP_001274096.1 nuclear pore complex protein Nup98-Nup96 isoform 5
NM_001404134.1 NP_001391063.1 nuclear pore complex protein Nup98-Nup96 isoform 6
NM_001404135.1 NP_001391064.1 nuclear pore complex protein Nup98-Nup96 isoform 6
NM_001404136.1 NP_001391065.1 nuclear pore complex protein Nup98-Nup96 isoform 7
NM_001404137.1 NP_001391066.1 nuclear pore complex protein Nup98-Nup96 isoform 3
NM_001404138.1 NP_001391067.1 nuclear pore complex protein Nup98-Nup96 isoform 8
NM_001404139.1 NP_001391068.1 nuclear pore complex protein Nup98-Nup96 isoform 9
NM_001404140.1 NP_001391069.1 nuclear pore complex protein Nup98-Nup96 isoform 5
NM_001404141.1 NP_001391070.1 nuclear pore complex protein Nup98-Nup96 isoform 10
NM_022979.3 NP_075355.1 nuclear pore complex protein Nup98-Nup96 isoform 2

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15615787 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear pore complex protein Nup98-Nup96

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-119264 PRLX-93936 98.31% Phase 2

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-170430 HGC652 Ligand 98.86% Unkown
HY-119264A PRLX-93936 dihydrochloride 99.83% Unkown
HY-169325 (S)-ACE-OH 99.17% Unkown
HY-180654A JWZ-8-103 hydrochloride Modulator 99.93% Unkown
HY-169355 TrimTAC1 Degrader / Unkown
HY-180654 JWZ-8-103 Modulator 98.04% Unkown
HY-141878 di-Ellipticine-RIBOTAC / Unkown
HY-141878A di-Ellipticine-RIBOTAC TFA / Unkown
HY-RS09701 NUP98 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nup98 NCBI NCBI:4928