STK36 - serine/threonine kinase 36 Gene

Also Known as FU; CILD46

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27148

About STK36

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,672,086-218,702,717 (from NCBI)

This gene has 16 transcripts (splice variants), 201 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in testis (RPKM 24.8), gall bladder (RPKM 6.4) and 21 other tissues.

Summary

This gene encodes a member of the serine/threonine kinase family of Enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the Gli zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

STK36 Products (3)

mRNA	Protein	Name
NM_001243313.2	NP_001230242.1	serine/threonine-protein kinase 36 isoform 2
NM_001369423.1	NP_001356352.1	serine/threonine-protein kinase 36 isoform 1
NM_015690.5	NP_056505.2	serine/threonine-protein kinase 36 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10806483	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	31279575	GOA
enables transcription corepressor binding	IDA IDA: Inferred from direct assay	10806483	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in axoneme assembly	IMP IMP: Inferred from mutant phenotype	28543983	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	28543983	GOA
involved in regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10806483	GOA
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	31279575	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10806483	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10806483	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK36 Protein Structure

Pkinase

HEAT_2

0
300
600
900
1200
1315 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase 36	fused homolog

STK36 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STK36	Q9NRP7	SUFU	Homo sapiens	Q9UMX1	Anti Tag CoIP	10806483

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ciliary Dyskinesia, Primary, 46	CILD46
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Congenital Hydrocephalus	Hydrocephalus Hydrocephalus Adverse Event Hydrocephalus, Nonsyndromic, Autosomal Recessive 1 Hydrocephalus In Newborn Congenital Hydrocephaly
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Cervical Large Cell Neuroendocrine Carcinoma
Nivelon-Nivelon-Mabille Syndrome	Chondrodysplasia-Pseudohermaphroditism Syndrome NNMS Chondrodysplasia-Disorder Of Sex Development Syndrome Nivelon Nivelon Mabille Syndrome
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1
Brachydactyly, Type A1	Brachydactyly Type A1 BDA1 Farabee-Type Brachydactyly Farabee Type Brachydactyly Brachydactyly Farabee Type Brachydactyly, Farabee Type Brachydactyly A1 Brachydactyly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13937	STK36 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STK36	MGD	MGI:1920831
Rattus norvegicus	STK36	RGD	RGD:1307318
Macaca mulatta	STK36	VGNC	VGNC:78145
Canis familiaris	STK36	VGNC	VGNC:46918
Felis catus	STK36	VGNC	VGNC:65785
Bos taurus	STK36	VGNC	VGNC:35398
Others	STK36	NCBI