2. Gene
  3. Wnk3 - WNK lysine deficient protein kinase 3 Gene

Wnk3 - WNK lysine deficient protein kinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Prkwnk3; Wnk3-ps

Gene ID: 279561 | Gene type: protein coding

About Wnk3

Summary

Predicted to enable Chloride Channel Inhibitor activity; Potassium Channel Inhibitor activity; and protein serine/threonine kinase activity. Involved in negative regulation of pancreatic juice secretion. Acts upstream of or within cell volume homeostasis and maintenance of blood-brain barrier. Located in adherens junction and bicellular tight junction. Orthologous to human WNK3 (WNK lysine deficient protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Wnk3 Products(2)

mRNA Protein Name
NM_001271678.1 NP_001258607.1 serine/threonine-protein kinase WNK3 isoform 1
NM_001271679.1 NP_001258608.1 serine/threonine-protein kinase WNK3 isoform 2
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell volume homeostasis IMP
IMP: Inferred from mutant phenotype
27782176 MGI
acts upstream of or within maintenance of blood-brain barrier IMP
IMP: Inferred from mutant phenotype
27782176 MGI
involved in negative regulation of pancreatic juice secretion IMP
IMP: Inferred from mutant phenotype
21317537 MGI
acts upstream of peptidyl-threonine phosphorylation IMP
IMP: Inferred from mutant phenotype
27782176 MGI
acts upstream of regulation of monoatomic cation transmembrane transport IMP
IMP: Inferred from mutant phenotype
27782176 MGI
Cellular Component GO Annotation Evidence Reference Source
located in adherens junction IDA
IDA: Inferred from direct assay
16275913 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
16275913 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase WNK3

WNK lysine deficient protein kinase 3, pseudogene

protein kinase lysine-deficient 3

protein kinase with no lysine 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100626 WNK463 Inhibitor 99.75% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wnk3 NCBI NCBI:65267