SLC39A5 - solute carrier family 39 member 5 Gene

Also Known as ZIP5; MYP24; LZT-Hs7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 283375

About SLC39A5

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,230,051-56,237,846 (from NCBI)

This gene has 11 transcripts (splice variants), 161 orthologues, 6 paralogues and is associated with 1 phenotype. Biased expression in duodenum (RPKM 78.5), small intestine (RPKM 76.3) and 4 other tissues.

Summary

The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many Enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

SLC39A5 Products (2)

mRNA	Protein	Name
NM_001135195.1	NP_001128667.1	zinc transporter ZIP5 precursor
NM_173596.3	NP_775867.2	zinc transporter ZIP5 precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	24891338	GOA
involved in eye development	IMP IMP: Inferred from mutant phenotype	24891338	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC39A5 Protein Structure

Zip

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540 a.a.

Protein Preferred Names	Protein Names
zinc transporter ZIP5	ZRT/IRT-like protein 5

Related Diseases

Diseases	Alias
Myopia 24, Autosomal Dominant	MYP24 Myopia, Type 24, Autosomal Dominant
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted
Refractive Error	Refractive Errors
Acrodermatitis Enteropathica, Zinc-Deficiency Type	Acrodermatitis Enteropathica AEZ Enteropathica Brandt Syndrome Ae Acrodermatitis Enteropathica Zinc Deficiency Type Danbolt-Cross Syndrome Acrodermatitis Enteropathica, Zinc Deficiency Type Inherited Zinc Deficiency Acrodermatitis Enteropathica, Zinc Deficiency Danbolt-Closs Syndrome Primary Zinc Malabsorption Syndrome
Hypermanganesemia With Dystonia 2	HMNDYT2 Dystonia-Parkinsonism-Hypermanganesemia Syndrome Hypermanganesemia With Dystonia, Type 2
Hypermanganesemia With Dystonia 1	Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis HMNDYT1 Hmdpc Hypermanganesemia With Dystonia Polycythemia And Cirrhosis Dystonia/Parkinsonism, Hypermanganesemia, Polycythemia, Chronic Liver Disease Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Hypermanganesemia With Dystonia	Familial Manganese-Induced Neurotoxicity Hmndyt
Ehlers-Danlos Syndrome	Eds Cutis Hyperelastica Elastic Skin Ehlers-Danlos Syndromes Ed Syndrome Ehlers Danlos Syndrome Ehlers Danlos Disease Eds - [Ehlers-Danlos Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13236	SLC39A5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC39A5	VGNC	VGNC:82239
Mus musculus	SLC39A5	MGD	MGI:1919336
Felis catus	SLC39A5	VGNC	VGNC:65361
Bos taurus	SLC39A5	VGNC	VGNC:34865
Rattus norvegicus	SLC39A5	RGD	RGD:1310322
Others	SLC39A5	NCBI