SLC26A11 - solute carrier family 26 member 11 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 284129

About SLC26A11

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:80,220,427-80,253,500 (from NCBI)

This gene has 17 transcripts (splice variants), 213 orthologues and 9 paralogues. Ubiquitous expression in adrenal (RPKM 8.3), spleen (RPKM 6.4) and 25 other tissues.

Summary

This gene encodes a member of the solute linked carrier 26 family of Anion Exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

SLC26A11 Products (4)

mRNA	Protein	Name
NM_001166347.2	NP_001159819.1	sodium-independent sulfate anion transporter
NM_001166348.2	NP_001159820.1	sodium-independent sulfate anion transporter
NM_001166349.2	NP_001159821.1	sodium-independent sulfate anion transporter
NM_173626.4	NP_775897.3	sodium-independent sulfate anion transporter

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables monoatomic anion transmembrane transporter activity	IDA IDA: Inferred from direct assay	12626430	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in sulfate transmembrane transport	IDA IDA: Inferred from direct assay	12626430	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12626430	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12626430	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	20957757	GOA
located in membrane	IDA IDA: Inferred from direct assay	12626430	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12626430	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC26A11 Protein Structure

Sulfate_transp

STAS

0
100
200
300
400
500
606 a.a.

Protein Preferred Names	Protein Names
sodium-independent sulfate anion transporter	solute carrier family 26 (anion exchanger), member 11

Related Diseases

Diseases	Alias
Sialolithiasis	Sialolith Stone Of Salivary Gland Or Duct Salivary Gland Calculi Salivary Gland Stone Calculus Of Salivary Gland Or Duct Calculus Of Salivary Gland Salivary Calculus Salivary Gland Calculus Salivary Stone Salivary Duct Calculi Sialodocholithiasis
Pendred Syndrome	Goiter-Deafness Syndrome Deafness With Goiter PDS Thyroid Dyshormonogenesis 2b Tdh2b Autosomal Recessive Sensorineural Hearing Impairment And Goiter Pendred'S Syndrome Thyroid Hormonogenesis, Genetic Defect In, 2b Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b Congenital Hypothyroidism Due To Dyshormonogenesis 2b Genetic Defect In Thyroid Hormonogenesis 2b Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter Goiter-Hearing Loss Syndrome Goitre-Deafness Syndrome Goitre Deafness
Moyamoya Disease 1	Moyamoya Disease Spontaneous Occlusion Of The Circle Of Willis Mymy Progressive Intracranial Arterial Occlusion Moyamoya Syndrome MYMY1 Cerebrovascular Moyamoya Disease Moya-Moya Disease Progressive Intracranial Occlusive Arteropathy Idiopathic Moyamoya Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS13135	SLC26A11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC26A11	MGD	MGI:2444589
Felis catus	SLC26A11	VGNC	VGNC:65282
Canis familiaris	SLC26A11	VGNC	VGNC:46321
Bos taurus	SLC26A11	VGNC	VGNC:34776
Macaca mulatta	SLC26A11	VGNC	VGNC:77482
Rattus norvegicus	SLC26A11	RGD	RGD:1306178
Others	SLC26A11	NCBI