GRIN1 - glutamate ionotropic receptor NMDA type subunit 1 Gene

Homo sapiens

Also known as NR1; MRD8; GluN1; NMDA1; DEE101; NDHMSD; NDHMSR; NMD-R1; NMDAR1

Gene ID: 2902 | Gene type: protein coding

About GRIN1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,139,154-137,168,756 (from NCBI)

This gene has 17 transcripts (splice variants), 273 orthologues, 17 paralogues and is associated with 8 phenotypes. Restricted expression toward brain (RPKM 50.5).

Summary

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

GRIN1 Products(5)

mRNA	Protein	Name
NM_000832.7	NP_000823.4	glutamate receptor ionotropic, NMDA 1 isoform GluN1-4a precursor
NM_001185090.2	NP_001172019.1	glutamate receptor ionotropic, NMDA 1 isoform GluN1-3b precursor
NM_001185091.2	NP_001172020.1	glutamate receptor ionotropic, NMDA 1 isoform GluN1-5b precursor
NM_007327.4	NP_015566.1	glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor
NM_021569.4	NP_067544.1	glutamate receptor ionotropic, NMDA 1 isoform GluN1-2a precursor

GRIN1 Protein Structure

ANF_receptor

SBP_bac_3

Lig_chan

CaM_bdg_C0

0
200
400
600
800
938 a.a.

Protein Preferred Names

Protein Names

glutamate receptor ionotropic, NMDA 1

N-methyl-D-aspartate receptor channel, subunit zeta-1

Recombinant GRIN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72213	GRIN1 Protein, Human (His)	Q05586 (R19-Q559)	≥95%

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Or Without Hyperkinetic Movements And Seizures, Autosomal Recessive

NDHMSR

Neurodevelopmental Disorder With Hyperkinetic Movements With Or Without Seizures, Autosomal Recessive

Neurodevelopmental Disorder With Or Without Hyperkinetic Movements And Seizures, Autosomal Dominant

NDHMSD	Mental Retardation, Autosomal Dominant 8, Formerly
Mrd8, Formerly	Mrd8
Neurodevelopmental Disorder With Hyperkinetic Movements And With Or Without Seizures, Autosomal Dominant	Mental Retardation, Autosomal Dominant 8

Developmental And Epileptic Encephalopathy 101

DEE101

Autosomal Dominant Intellectual Developmental Disorder 8

Autosomal Dominant Non-Syndromic Intellectual Disability 8	Mental Retardation, Autosomal Dominant 8
Autosomal Dominant Mental Retardation 8	Mrd8

Bilateral Generalized Polymicrogyria

Bilateral Generalised Polymicrogyria

Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy	Benign Rolandic Epilepsy
Epilepsy, Rolandic	Bcects
Benign Childhood Epilepsy With Centrotemporal Spike	Sylvan Seizures
Becrs	Bects
Bre	Benign Epilepsy Of Childhood With Centrotemporal Spikes
Benign Familial Epilepsy Of Childhood With Rolandic Spikes	Centrotemporal Epilepsy

Autosomal Dominant Non-Syndromic Intellectual Disability

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression	Early Infantile Epileptic Encephalopathy With Suppression Bursts
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

Ocular Dominance

Febrile Seizures

Febrile Seizure	Febrile Convulsions
Seizures Febrile

Amblyopia

Lazy Eye

Morphine Dependence

Lingual-Facial-Buccal Dyskinesia

Orofacial Dyskinesia	Oro-Facial Dyskinesia
Dyskinesias

Cortical Blindness

Blindness, Cortical

Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

La Crosse Encephalitis

California Encephalitis	California Virus Encephalitis
Neuroinvasive California Encephalitis Virus Infection	Californian Encephalitis
Encephalitis, California	California Meningoencephalitis
California Encephalitis Virus Infection	California Encephalitis Virus Infection Neuroinvasive Disease
California Meningoencephalitis Virus Disease	California Serogroup Virus Neuroinvasive Disease
California Viral Encephalitis	Ce - [California Encephalitis]
Lac - [La Crosse Encephalitis]

Cataract 23, Multiple Types

Cataract 23	CTRCT23
Lamellar Cataract 23	Cataract 23, Multiple Types, With Or Without Microcornea
Isolated Microphthalmia With Cataract 4	Mcopct4
Cataract, Type 23	Microphthalmia, Isolated, With Cataract 4

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

High Pressure Neurological Syndrome

Temporal Lobe Neoplasm

Neoplasm Of Temporal Lobe	Malignant Neoplasm Of Temporal Lobe
Tumor Of Temporal Lobe

Status Epilepticus

Grand Mal Status Epilepticus	Grand Mal Status
Gcse	Generalized Convulsive Status Epilepticus
Se	Epilepsy With Status Epilepticus

Sudden Infant Death Syndrome

SIDS	Sudden Infant Death Syndrome, Susceptibility To
Cot Death	Crib Death
Sudden Death Of Nonspecific Cause In Infancy	Sudden Infant Death
Death, Sudden, Syndrome, Infant

Mutism

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Schizophrenia 7

SCZD7	Schizophrenia Susceptibility Locus, Chromosome 13q-Related
Schizophrenia 7 With Or Without An Affective Disorder

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Polymicrogyria

Pmg

Autosomal Dominant Intellectual Developmental Disorder 6

Autosomal Dominant Non-Syndromic Intellectual Disability 6	Autosomal Dominant Mental Retardation 6
Mrd6	Mental Retardation, Autosomal Dominant, Type 6
Mental Retardation, Autosomal Dominant 6

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Akinetopsia

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Landau-Kleffner Syndrome

Acquired Epileptic Aphasia	Lks
Acquired Aphasia With Convulsive Disorder	Acquired Epileptiform Aphasia
Landau Kleffner Syndrome	Childhood Epileptic Aphasia

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Speech Disorder

Speech Disorders

Drug-Induced Mental Disorder

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05803	GRIN1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GRIN1	RGD	RGD:2736
Macaca mulatta	GRIN1	VGNC	VGNC:73281
Mus musculus	GRIN1	MGD	MGI:95819
Canis familiaris	GRIN1	VGNC	VGNC:41491
Bos taurus	GRIN1	VGNC	VGNC:29645
Felis catus	GRIN1	VGNC	VGNC:82437
Others	GRIN1	NCBI