Mylk3 - myosin light chain kinase 3 Gene

Rattus norvegicus

Also known as MLCK; RGD1305801

Gene ID: 291926 | Gene type: protein coding

About Mylk3

Summary

Enables calmodulin-dependent protein kinase activity and Myosin light chain kinase activity. Involved in myofibril assembly; positive regulation of sarcomere organization; and protein phosphorylation. Located in cytosol. Orthologous to human MYLK3 (Myosin light chain kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Mylk3 Products(1)

mRNA	Protein	Name
NM_001110810.1	NP_001104280.1	myosin light chain kinase 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium/calmodulin-dependent protein kinase activity	IDA IDA: Inferred from direct assay	17885681	RGD
enables myosin light chain kinase activity	IMP IMP: Inferred from mutant phenotype	18202317	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac myofibril assembly	IMP IMP: Inferred from mutant phenotype	17885681	RGD
involved in positive regulation of sarcomere organization	IDA IDA: Inferred from direct assay	17885681	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	17885681	RGD
involved in sarcomere organization	IMP IMP: Inferred from mutant phenotype	18202317	RGD
involved in sarcomerogenesis	IMP IMP: Inferred from mutant phenotype	17885681	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	17885681	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myosin light chain kinase 3

cardiac-MLCK	cardiac-MyBP-C-associated Ca/CaM kinase
putative myosin light chain kinase 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08925	MYLK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22661	Mylk3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29175	Mylk3 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mylk3	NCBI	NCBI:91807

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