MYLK3 - myosin light chain kinase 3 Gene

Homo sapiens

Also known as MLCK; MLCK2; caMLCK

Gene ID: 91807 | Gene type: protein coding

About MYLK3

Cytogenetic location: 16q11.2 Genomic coordinates (GRCh38): 16:46,702,282-46,763,246 (from NCBI)

This gene has 7 transcripts (splice variants), 152 orthologues and 22 paralogues. Biased expression in heart (RPKM 28.3), testis (RPKM 4.8) and 2 other tissues.

Summary

Phosphorylation of cardiac Myosin heavy chains (see MYH7B, MIM 609928) and LIGHT chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]

MYLK3 Products(2)

mRNA	Protein	Name
NM_001308301.1	NP_001295230.1	myosin light chain kinase 3 isoform 2
NM_182493.3	NP_872299.2	myosin light chain kinase 3 isoform 1

MYLK3 Protein Structure

Pkinase

0
200
400
600
819 a.a.

Protein Preferred Names

Protein Names

myosin light chain kinase 3

MLC kinase

Related Diseases

Diseases

Alias

Hypoplastic Right Heart Syndrome

Right Hypoplastic Heart Syndrome

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08925	MYLK3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MYLK3	VGNC	VGNC:75045
Mus musculus	MYLK3	MGD	MGI:2443063
Bos taurus	MYLK3	VGNC	VGNC:31807
Canis familiaris	MYLK3	VGNC	VGNC:43551
Felis catus	MYLK3	VGNC	VGNC:63682
Rattus norvegicus	MYLK3	RGD	RGD:1305801

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