MYLK3 - myosin light chain kinase 3 Gene

Also Known as MLCK; MLCK2; caMLCK

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91807

About MYLK3

Cytogenetic location: 16q11.2 Genomic coordinates (GRCh38): 16:46,702,282-46,763,246 (from NCBI)

This gene has 7 transcripts (splice variants), 152 orthologues and 22 paralogues. Biased expression in heart (RPKM 28.3), testis (RPKM 4.8) and 2 other tissues.

Summary

Phosphorylation of cardiac Myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]

MYLK3 Products (2)

mRNA Protein Name
NM_001308301.1 NP_001295230.1 myosin light chain kinase 3 isoform 2
NM_182493.3 NP_872299.2 myosin light chain kinase 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
36931259 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to interleukin-1 IMP
IMP: Inferred from mutant phenotype
18390750 GOA
involved in regulation of vascular permeability involved in acute inflammatory response IMP
IMP: Inferred from mutant phenotype
18390750 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYLK3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (517 - 770)

  • 0
  • 200
  • 400
  • 600
  • 819 a.a.
Protein Preferred Names Protein Names

myosin light chain kinase 3

  • MLC kinase

MYLK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MYLK3 Q32MK0 YWHAE Homo sapiens P62258
Crosslink
36931259
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypoplastic Right Heart Syndrome

  • Right Hypoplastic Heart Syndrome
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08925 MYLK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22661 Mylk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29175 Mylk3 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MYLK3 VGNC VGNC:75045
Mus musculus MYLK3 MGD MGI:2443063
Bos taurus MYLK3 VGNC VGNC:31807
Canis familiaris MYLK3 VGNC VGNC:43551
Felis catus MYLK3 VGNC VGNC:63682
Rattus norvegicus MYLK3 RGD RGD:1305801
Others MYLK3 NCBI