Pla2g5 - phospholipase A2, group V Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29354

Summary

Enables calcium-dependent Phospholipase A2 activity and heparin binding activity. Involved in several processes, including arachidonic acid secretion; leukotriene biosynthetic process; and platelet activating factor biosynthetic process. Located in Golgi apparatus; perinuclear region of cytoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in familial benign fleck retina. Orthologous to human PLA2G5 (Phospholipase A2 group V). [provided by Alliance of Genome Resources, Apr 2022]

Pla2g5 Products (1)

mRNA Protein Name
NM_017174.2 NP_058870.1 phospholipase A2 group V precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent phospholipase A2 activity IDA
IDA: Inferred from direct assay
7947992 RGD
enables heparin binding IDA
IDA: Inferred from direct assay
9603953 RGD
Biological Process GO Annotation Evidence References Source
involved in arachidonate secretion IDA
IDA: Inferred from direct assay
11106649 RGD
involved in leukotriene biosynthetic process IDA
IDA: Inferred from direct assay
11106649 RGD
involved in platelet activating factor biosynthetic process IDA
IDA: Inferred from direct assay
11106649 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
11341961 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
11341961 RGD
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11341961 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phospholipase A2 group V

  • PLA2-10

  • calcium-dependent phospholipase A2

  • group V phospholipase A2

  • phosphatidylcholine 2-acylhydrolase 5

  • phospholipase A2, group 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10632 PLA2G5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-184012 BAY-163 Control / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pla2g5 NCBI NCBI:5322